CUB domain is an evolutionarily conserved protein domain. The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated.[1][2] These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression.[3] Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin).
^Bork P, Beckmann G (May 1993). "The CUB domain. A widespread module in developmentally regulated proteins". Journal of Molecular Biology. 231 (2): 539–45. doi:10.1006/jmbi.1993.1305. PMID 8510165.
^Bork P (Apr 1991). "Complement components C1r/C1s, bone morphogenic protein 1 and Xenopus laevis developmentally regulated protein UVS.2 share common repeats". FEBS Letters. 282 (1): 9–12. doi:10.1016/0014-5793(91)80433-4. PMID 2026272. S2CID 33375087.
^Perry SE, Robinson P, Melcher A, Quirke P, Bühring HJ, Cook GP, Blair GE (Mar 2007). "Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells". FEBS Letters. 581 (6): 1137–42. doi:10.1016/j.febslet.2007.02.025. PMID 17335815. S2CID 30701692.
CUBdomain is an evolutionarily conserved protein domain. The CUBdomain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110...
CUBdomain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. CDCP1 has also been designated as CD318 (cluster of differentiation...
Lone Wolf and Cub (Japanese: 子連れ狼, Hepburn: Kozure Ōkami, "Wolf taking along his child") is a Japanese manga series created by writer Kazuo Koike and...
Signal peptide, CUBdomain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene. This gene encodes a cell surface...
C-terminus of procollagen I, II and III. It has an astacin-like protease domain. It has been shown to cleave laminin 5 and is localized in the basal epithelial...
factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUBdomain. PDGF-C is a key component of the PDGFR-α signaling pathway and...
complement B-type domains, C-type lectin domains, von Willebrand type A domains, CUBdomains, discoidin lectin domains or CAP domains. It has been proposed...
and beta members of this family in having an unusual N-terminal domain, the CUBdomain. Two splice variants have been identified for this gene. GRCh38:...
transmembrane protein containing two extracellular CUBdomains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein...
eukaryotes (/juːˈkærioʊts, -əts/ yoo-KARR-ee-ohts, -əts) constitute the domain of Eukarya or Eukaryota, organisms whose cells have a membrane-bound nucleus...
CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the CSMD1 gene. CSMD1 contains 14 N-terminal CUBdomains that are separated...
B12 complexes. The role of receptor is supported by the presence of 27 CUBdomains. Cubilin shows a restricted mode of expression according to protein profiling...
(VLPs) and inhibiting them from leaving the cell surface. CD318 CDCP1, (CUBdomain-containing protein 1) and Trask (Transmembrane and associated with src...
for both males and female juveniles of one to two years of age. Causes of cub mortality include predators, floods, fires, death of the mother and fatal...
RNA-binding proteins with 2 or 3 domains: The N-terminal PAZ domain binds the 3'-end of the guide RNA; the middle MID domain binds the 5'-phosphate of RNA;...
are generally lighter. A new-born lion has dark spots, which fade as the cub reaches adulthood, although faint spots may still be seen on the legs and...
in the Serengeti, 30% of members in coalitions are unrelated males. If a cub is the only male in a litter, he will typically join an existing group, or...
shark, river shark, freshwater whaler, estuary whaler, Swan River whaler, cub shark, and shovelnose shark. Some of the bull shark's closest living relatives...
Global Information