PDGFC information

PDGFC
Identifiers
Aliases	PDGFC, FALLOTEIN, SCDGF, platelet derived growth factor C
External IDs	OMIM: 608452; MGI: 1859631; HomoloGene: 9423; GeneCards: PDGFC; OMA:PDGFC - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	156,971,799 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	81,121,347 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; germinal epithelium; ; tibia; ; parietal pleura; ; periodontal fiber; ; skin of hip; ; kidney tubule; ; metanephric glomerulus; ; seminal vesicula; ; stromal cell of endometrium;
	Top expressed in
	gastrula; ; vas deferens; ; efferent ductule; ; calvaria; ; internal carotid artery; ; tunica media of zone of aorta; ; renal corpuscle; ; vestibular sensory epithelium; ; stroma of bone marrow; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; growth factor activity; platelet-derived growth factor receptor binding;
Cellular component	Golgi membrane; nucleus; extracellular region; endoplasmic reticulum lumen; membrane; cell surface; extracellular exosome; plasma membrane; extracellular space; cytoplasm; cytosol;
Biological process	positive regulation of ERK1 and ERK2 cascade; cellular response to amino acid stimulus; positive regulation of cell population proliferation; bone development; positive regulation of protein autophosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; multicellular organism development; activation of transmembrane receptor protein tyrosine kinase activity; central nervous system development; embryo development; positive regulation of cell division; positive regulation of cell migration; positive regulation of DNA replication; positive regulation of MAP kinase activity; animal organ morphogenesis; digestive tract development; regulation of peptidyl-tyrosine phosphorylation; positive regulation of fibroblast proliferation; platelet-derived growth factor receptor signaling pathway; blood coagulation; regulation of signaling receptor activity; embryonic organ development; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	56034
	54635
	ENSG00000145431
	ENSMUSG00000028019
	Q9NRA1
	Q8CI19
	NM_016205
	NM_019971; NM_001357746
	NP_057289
	NP_064355; NP_001344675
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet-derived growth factor C, also known as PDGF-C, is a 345-amino acid protein that in humans is encoded by the PDGFC gene.^[5]^[6] Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide-linked dimers involving two polypeptide chains, PDGF-A and PDGF-B. PDGF-C is a member of the PDGF/VEGF family of growth factors with a unique two-domain structure and expression pattern. PDGF-C was not previously identified with PDGF-A and PDGF-B, possibly because it may be that it is synthesized and secreted as a latent growth factor, requiring proteolytic removal of the N-terminal CUB domain for receptor binding and activation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145431 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028019 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamada T, Ui-Tei K, Miyata Y (June 2000). "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family". FEBS Lett. 475 (2): 97–102. doi:10.1016/S0014-5793(00)01640-9. PMID 10858496. S2CID 19634520.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U (May 2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor". Nat. Cell Biol. 2 (5): 302–9. doi:10.1038/35010579. PMID 10806482. S2CID 25066476.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145431 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028019 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10858496-5] Hamada T, Ui-Tei K, Miyata Y (June 2000). "A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family". FEBS Lett. 475 (2): 97–102. doi:10.1016/S0014-5793(00)01640-9. PMID 10858496. S2CID 19634520.

[entrez-6] Cite error: The named reference entrez was invoked but never defined (see the help page).

[pmid10806482-7] Li X, Pontén A, Aase K, Karlsson L, Abramsson A, Uutela M, Bäckström G, Hellström M, Boström H, Li H, Soriano P, Betsholtz C, Heldin CH, Alitalo K, Ostman A, Eriksson U (May 2000). "PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor". Nat. Cell Biol. 2 (5): 302–9. doi:10.1038/35010579. PMID 10806482. S2CID 25066476.

PDGFC information

and 5 Related for: PDGFC information

PDGFC

CUB domain

PDGFD

FaceBase

Crenolanib