CREB3 information

CREB3
Identifiers
Aliases	CREB3, LUMAN, LZIP, sLZIP, cAMP responsive element binding protein 3
External IDs	OMIM: 606443 MGI: 99946 HomoloGene: 31375 GeneCards: CREB3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,736,999 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,567,060 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; popliteal artery; ; ascending aorta; ; right adrenal gland; ; left adrenal gland; ; left coronary artery; ; right coronary artery; ; gastric mucosa; ; cingulate gyrus; ; stromal cell of endometrium;
	Top expressed in
	ascending aorta; ; aortic valve; ; Paneth cell; ; supraoptic nucleus; ; calvaria; ; substantia nigra; ; pituitary gland; ; facial motor nucleus; ; motor neuron; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; protein dimerization activity; cAMP response element binding protein binding; DNA-binding transcription factor activity; CCR1 chemokine receptor binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; protein binding; cAMP response element binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; integral component of membrane; nuclear body; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; neuronal cell body; endoplasmic reticulum; nucleus; cytosol; Golgi membrane; nucleoplasm; Golgi apparatus;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; regulation of transcription, DNA-templated; release from viral latency; positive regulation of cell migration; cytoplasmic sequestering of transcription factor; negative regulation of cell cycle; positive regulation of monocyte chemotaxis; transcription, DNA-templated; response to endoplasmic reticulum stress; induction of positive chemotaxis; positive regulation of transcription, DNA-templated; chemotaxis; response to unfolded protein; regulation of cell population proliferation; regulation of cell growth; establishment of viral latency; positive regulation of deacetylase activity; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; viral process; positive regulation of transcription by RNA polymerase II; positive regulation of defense response to virus by host; positive regulation of calcium ion transport; transcription by RNA polymerase II; endoplasmic reticulum unfolded protein response; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	10488
	12913
	ENSG00000107175
	ENSMUSG00000028466
	O43889
	Q61817
	NM_006368
	NM_013497
	NP_006359
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.^[5]^[6]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107175 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028466 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol. 17 (9): 5117–26. doi:10.1128/MCB.17.9.5117. PMC 232362. PMID 9271389.
^ ^a ^b "Entrez Gene: CREB3 cAMP responsive element binding protein 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107175 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028466 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9271389-5] Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol. 17 (9): 5117–26. doi:10.1128/MCB.17.9.5117. PMC 232362. PMID 9271389.

[entrez-6] "Entrez Gene: CREB3 cAMP responsive element binding protein 3".

CREB3 information

and 11 Related for: CREB3 information

CREB3

CREBRF

CREB

List of human transcription factors

Chromosome 5

TMEM19

GLUT1

BZIP domain

HERPUD1

CREB3L1

Host cell factor C1