CORO1A information

CORO1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AKF, 2AQ5, 2B4E
Identifiers
Aliases	CORO1A, CLABP, CLIPINA, HCORO1, IMD8, TACO, p57, coronin 1A
External IDs	OMIM: 605000 MGI: 1345961 HomoloGene: 6545 GeneCards: CORO1A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,189,076 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,306,959 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; appendix; ; bone marrow; ; bone marrow cells; ; lymph node; ; trabecular bone; ; thymus; ; gallbladder;
	Top expressed in
	thymus; ; spleen; ; blood; ; bone marrow; ; right lung lobe; ; prefrontal cortex; ; submandibular gland; ; ankle joint; ; subiculum; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein C-terminus binding; identical protein binding; phosphatidylinositol 3-kinase binding; protein homodimerization activity; actin monomer binding; myosin heavy chain binding; cytoskeletal protein binding; actin filament binding; actin binding;
Cellular component	phagocytic cup; extracellular exosome; cytoplasm; actin cytoskeleton; cell cortex; nucleus; cell leading edge; axon; lamellipodium; cortical actin cytoskeleton; early endosome; cell-cell junction; membrane; actin filament; phagocytic vesicle membrane; plasma membrane; cytoplasmic vesicle; immunological synapse; cytoskeleton; phagocytic vesicle; cytosol;
Biological process	negative regulation of vesicle fusion; calcium ion transport; homeostasis of number of cells within a tissue; negative regulation of actin nucleation; phagocytosis; response to cytokine; nerve growth factor signaling pathway; T cell homeostasis; positive regulation of cell migration; regulation of actin cytoskeleton organization; positive chemotaxis; actin filament organization; positive regulation of T cell proliferation; cellular response to interleukin-4; natural killer cell degranulation; regulation of release of sequestered calcium ion into cytosol; regulation of actin polymerization or depolymerization; cell-substrate adhesion; regulation of actin filament polymerization; negative regulation of neuron apoptotic process; positive regulation of T cell activation; regulation of cell shape; innate immune response; early endosome to recycling endosome transport; cell migration; actin cytoskeleton organization; uropod organization; immunological synapse formation; leukocyte chemotaxis; phagolysosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	11151
	12721
	ENSG00000102879
	ENSMUSG00000030707
	P31146
	O89053
	NM_001193333; NM_007074
	NM_001301374; NM_009898
	NP_001180262; NP_009005
	NP_001288303; NP_034028
	Wikidata
View/Edit Human	View/Edit Mouse

Coronin-1A is a protein that in humans is encoded by the CORO1A gene.^[5]^[6] It has been implicated in both T-cell mediated immunity and mitochondrial apoptosis. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102879 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Sep 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA and Cell Biology. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
^ "Entrez Gene: CORO1A coronin, actin binding protein, 1A".
^ Kerber RA, O'Brien E, Cawthon RM (Jun 2009). "Gene expression profiles associated with aging and mortality in humans". Aging Cell. 8 (3): 239–50. doi:10.1111/j.1474-9726.2009.00467.x. PMC 2759984. PMID 19245677.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102879 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030707 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9778037-5] Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Sep 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA and Cell Biology. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.

[entrez-6] "Entrez Gene: CORO1A coronin, actin binding protein, 1A".

[aging-7] Kerber RA, O'Brien E, Cawthon RM (Jun 2009). "Gene expression profiles associated with aging and mortality in humans". Aging Cell. 8 (3): 239–50. doi:10.1111/j.1474-9726.2009.00467.x. PMC 2759984. PMID 19245677.

CORO1A information

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