calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
apical junction assembly
neuronal action potential propagation
response to stimulus
visual perception
tight junction organization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
149461
242653
Ensembl
ENSG00000164007
ENSMUSG00000066058
UniProt
Q8N6F1
Q9ET38
RefSeq (mRNA)
NM_148960 NM_001123395 NM_001185117
NM_001038590 NM_153105
RefSeq (protein)
NP_001116867 NP_001172046 NP_683763
NP_001033679 NP_694745
Location (UCSC)
Chr 1: 42.73 – 42.74 Mb
Chr 4: 119.11 – 119.12 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.[5] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.[6][7]
Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM][5]
^ abcGRCh38: Ensembl release 89: ENSG00000164007 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000066058 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: CLDN19 claudin 19".
^Naeem M, Hussain S, Akhtar N (2011). "Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular Disease". American Journal of Nephrology. 34 (3): 241–248. doi:10.1159/000330854. PMID 21791920.
^Konrad M, Schaller A, Seelow D, Pandey AV, Waldegger S, Lesslauer A, Vitzthum H, Suzuki Y, Luk JM, Becker C, Schlingmann KP, Schmid M, Rodriguez-Soriano J, Ariceta G, Cano F, Enriquez R, Jüppner H, Bakkaloglu SA, Hediger MA, Gallati S, Neuhauss SC, Nürnberg P, Weber S (2006). "Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement". The American Journal of Human Genetics. 79 (5): 949–957. doi:10.1086/508617. PMC 1698561. PMID 17033971.
encoded by the CLDN19 gene. It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport. Claudins, such as CLDN19, are transmembrane...
syndromes, which encompass the syndromes caused by mutations in CLDN16, CLDN19, CASR or CLCNKB. In these diseases, reabsorption of divalent cations (such...
reuptake of Mg2+ in the human kidney. Some patients with mutations in the CLDN19 gene also have altered magnesium transport. The gene Claudin-16 was cloned...