CDC73 information

CDC73
Identifiers
Aliases	CDC73, C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX, cell division cycle 73
External IDs	OMIM: 607393; MGI: 2384876; HomoloGene: 11571; GeneCards: CDC73; OMA:CDC73 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	193,254,815 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,578,631 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; monocyte; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium; ; gonad; ; tail of epididymis; ; right ventricle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; seminal vesicula; ; cumulus cell; ; primitive streak; ; epiblast; ; medial ganglionic eminence; ; yolk sac; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II complex binding; protein binding;
Cellular component	nucleoplasm; Cdc73/Paf1 complex; nucleus; cytosol;
Biological process	histone monoubiquitination; regulation of transcription, DNA-templated; positive regulation of mRNA 3'-end processing; histone modification; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; stem cell population maintenance; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of Wnt signaling pathway; mRNA polyadenylation; endodermal cell fate commitment; protein destabilization; negative regulation of epithelial cell proliferation; cell cycle; histone H2B ubiquitination; cellular response to lipopolysaccharide; negative regulation of myeloid cell differentiation; negative regulation of fibroblast proliferation; positive regulation of transcription elongation from RNA polymerase II promoter; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; beta-catenin-TCF complex assembly; regulation of cell growth; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; negative regulation of apoptotic process; positive regulation of cell cycle G1/S phase transition;
	Sources:Amigo / QuickGO
Orthologs
	79577
	214498
	ENSG00000134371
	ENSMUSG00000026361
	Q6P1J9
	Q8JZM7
	NM_024529
	NM_145991
	NP_078805
	NP_666103
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026361 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CDC73 Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".
^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
^ Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR (December 2002). "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nat. Genet. 32 (4): 676–80. doi:10.1038/ng1048. PMID 12434154. S2CID 23713328.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134371 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026361 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "Entrez Gene: CDC73 Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

[pmid11318611-6] Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.

[pmid12434154-7] Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR (December 2002). "HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome". Nat. Genet. 32 (4): 676–80. doi:10.1038/ng1048. PMID 12434154. S2CID 23713328.

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