Burkholderia cenocepacia is a Gram-negative, rod-shaped bacterium that is commonly found in soil and water environments and may also be associated with plants and animals, particularly as a human pathogen.[1] It is one of over 20 species in the Burkholderia cepacia complex (Bcc) and is notable due to its virulence factors and inherent antibiotic resistance that render it a prominent opportunistic pathogen responsible for life-threatening, nosocomial infections in immunocompromised patients, such as those with cystic fibrosis or chronic granulomatous disease.[2] The quorum sensing systems CepIR and CciIR regulate the formation of biofilms and the expression of virulence factors such as siderophores and proteases.[3]Burkholderia cenocepacia may also cause disease in plants, such as in onions[4][5] and bananas.[6] Additionally, some strains serve as plant growth-promoting rhizobacteria.[7]
^O'Grady EP, Sokol PA (2011-12-09). "Burkholderia cenocepacia differential gene expression during host-pathogen interactions and adaptation to the host environment". Frontiers in Cellular and Infection Microbiology. 1: 15. doi:10.3389/fcimb.2011.00015. PMC 3417382. PMID 22919581.
^Lauman P, Dennis JJ (July 2021). "Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex". Viruses. 13 (7): 1331. doi:10.3390/v13071331. PMC 8310193. PMID 34372537.
^Scoffone VC, Chiarelli LR, Makarov V, Brackman G, Israyilova A, Azzalin A, et al. (September 2016). "Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo". Scientific Reports. 6 (1): 32487. doi:10.1038/srep32487. PMC 5007513. PMID 27580679.
^da Silva PH, de Assunção EF, da Silva Velez L, Dos Santos LN, de Souza EB, da Gama MA (December 2021). "Biofilm formation by strains of Burkholderia cenocepacia lineages IIIA and IIIB and B. gladioli pv. alliicola associated with onion bacterial scale rot". Brazilian Journal of Microbiology. 52 (4): 1665–1675. doi:10.1007/s42770-021-00564-6. PMC 8578472. PMID 34351603.
^Jacobs JL, Fasi AC, Ramette A, Smith JJ, Hammerschmidt R, Sundin GW (May 2008). "Identification and onion pathogenicity of Burkholderia cepacia complex isolates from the onion rhizosphere and onion field soil". Applied and Environmental Microbiology. 74 (10): 3121–3129. Bibcode:2008ApEnM..74.3121J. doi:10.1128/AEM.01941-07. PMC 2394932. PMID 18344334.
^Lee YA, Chan CW (February 2007). "Molecular Typing and Presence of Genetic Markers Among Strains of Banana Finger-Tip Rot Pathogen, Burkholderia cenocepacia, in Taiwan". Phytopathology. 97 (2): 195–201. doi:10.1094/PHYTO-97-2-0195. PMID 18944375.
^You M, Fang S, MacDonald J, Xu J, Yuan ZC (March 2020). "Isolation and characterization of Burkholderia cenocepacia CR318, a phosphate solubilizing bacterium promoting corn growth". Microbiological Research. 233: 126395. doi:10.1016/j.micres.2019.126395. PMID 31865096. S2CID 209445961.
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Burkholderiacenocepacia is a Gram-negative, rod-shaped bacterium that is commonly found in soil and water environments and may also be associated with...
Burkholderia cepacia complex (BCC) is a species complex consisting of Burkholderia cepacia and at least 20 different biochemically similar species of Gram-negative...
into the cell. Ornibactin is produced by Burkholderiacenocepacia under iron-deficient conditions. B. cenocepacia is known to opportunistically infect humans...
for low-pH tolerance, antimicrobial resistance, and motility in Burkholderiacenocepacia". Journal of Bacteriology. 193 (23): 6712–23. doi:10.1128/JB.05979-11...
biofilms are present in the chronic Pseudomonas aeruginosa and Burkholderiacenocepacia infections characteristic of cystic fibrosis. Type I interferons...
these opportunistic pathogens include Pseudomonas aeruginosa, Burkholderiacenocepacia, and Mycobacterium avium. Obligate intracellular parasites (e.g...
humans, such as Salmonella, enterohaemorhagic Escherichia coli, Burkholderiacenocepacia, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia, can...
15, bacteria had colonized Smith's lungs, including a form of Burkholderiacenocepacia which mutated over a decade of antibiotic treatment from a normal...
successful infections, such as the chronic Pseudomonas aeruginosa and Burkholderiacenocepacia infections characteristic of cystic fibrosis. Other bacteria generate...
phases. Characterization of the secondary structures of 4 tsRNAs in Burkholderiacenocepacia suggests they form double hairpin structures. Sometimes, this...
coronary heart disease. Some species, such as Pseudomonas aeruginosa, Burkholderiacenocepacia, and Mycobacterium avium, are opportunistic pathogens and cause...
for low-pH tolerance, antimicrobial resistance, and motility in Burkholderiacenocepacia". Journal of Bacteriology. 193 (23): 6712–6723. doi:10.1128/JB...
Cis-Encoded Small RNA h2cR Is a Negative Regulator of hfq2 in Burkholderiacenocepacia". PLOS ONE. 7 (10): e47896. Bibcode:2012PLoSO...747896R. doi:10...
diffusible signal factors (DSFs) have been found in bacteria such as Burkholderiacenocepacia and Pseudomonas aeruginosa. When individual cells are stimulated...
have a higher virulence when it is shared. This is found when Burkholderiacenocepacia and Stenotrophomonas maltophilia's diffusible signal factor is...