Bacterial small RNAs (sRNA) are an important class of regulatory molecules in bacteria such as Brucella. They are often bound to the chaperone protein Hfq, which allows them to interact with mRNA(s). In Brucella suis 1330 RNA sequencing identified a novel list of 33 sRNAs and 62 Hfq-associated mRNAs.[1] In Brucella melitensis eight novel sRNA genes were identified using bioinformatic and experimental approach. One of them BSR0602 was found to modulate the intracellular survival of B. melitensis.[2] In another large-scale deep sequencing study 1321 sRNAs were identified in B. melitensis.[3] BSR0441 sRNA was further investigated in this study and shown to play role in the intracellular survival. sRNA BM-sr0117 from Brucella melitensis was identified and shown to be bound to and cleaved by Bm-RNase III.[4] AbcR and AbcR2 (orthologs of SmrC15 and SmrC16) were studied B. abortus.[5] Seven novel sRNAs were validated and their interaction with a putative target sequence was verified in B. abortus.[6]
^Saadeh, B; et al. (2015). "Transcriptome-Wide Identification of Hfq-Associated RNAs in Brucella suis by Deep Sequencing". J. Bacteriol. 198 (3): 427–435. doi:10.1128/JB.00711-15. PMC 4719455. PMID 26553849.
^Wang, Y; et al. (2015). "Identification of a Novel Small Non-Coding RNA Modulating the Intracellular Survival of Brucella melitensis". Front. Microbiol. 6: 164. doi:10.3389/fmicb.2015.00164. PMC 4365724. PMID 25852653.
^Zhong, Zhijun; Xu, Xiaoyang; Li, Xinran; Liu, Shiwei; Lei, Shuangshuang; Yang, Mingjuan; Yu, Jiuxuan; Yuan, Jiuyun; Ke, Yuehua (2016-01-01). "Large-scale identification of small noncoding RNA with strand-specific deep sequencing and characterization of a novel virulence-related sRNA in Brucella melitensis". Scientific Reports. 6: 25123. Bibcode:2016NatSR...625123Z. doi:10.1038/srep25123. ISSN 2045-2322. PMC 4845025. PMID 27112796.
^Wu, CX; et al. (2016). "Characterization of ribonuclease III from Brucella". Gene. 579 (2): 183–192. doi:10.1016/j.gene.2015.12.068. PMID 26778206.
^Caswell, Clayton C.; Gaines, Jennifer M.; Ciborowski, Pawel; Smith, Derek; Borchers, Christoph H.; Roux, Christelle M.; Sayood, Khalid; Dunman, Paul M.; Roop Ii, R. Martin (2012-07-01). "Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308". Molecular Microbiology. 85 (2): 345–360. doi:10.1111/j.1365-2958.2012.08117.x. ISSN 1365-2958. PMC 3391331. PMID 22690807.
Bacterial small RNAs (sRNA) are an important class of regulatory molecules in bacteria such as Brucella. They are often bound to the chaperone protein...
handle.net/11056/23125. Bacterial small RNAs (sRNA) are an important class of regulatory molecules. Many BrucellasRNAs have been identified.[citation needed]...
first sRNA identified as a potential biomarker for the detection of MTB in patients. Bacillus subtilis sRNAs Bacterial small RNABrucellasRNA Bacteroides...
Small nonprotein-coding RNAs (sRNA) are able to perform specific functions without being translated into proteins; 97 bacterial sRNAs from Salmonella Typhi...
biological processes, binding to mRNA and protein targets in prokaryotes. Their phylogenetic analyses, for example through sRNA–mRNA target interactions or protein...
PMC 145300. PMID 12525425. Brucella+vaccine at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Heidary M, Dashtbin S, Ghanavati R, Mahdizade...
sRNA-ome. Among them was Yersinia-specific (also present in Y. pseudotuberculosis and Y. enterocolitica) Ysr141 (Yersinia small RNA 141). Ysr141 sRNA...
Francisella colonies bear a morphological resemblance to those of the genus Brucella. Some Francisella species are pathogenic bacteria but some others are endosymbionts...
quantified 70 sRNAs and further identified 17 differentially expressed sRNAs during growth phases. Target prediction indicated possibility of sRNA interaction...
Bacterial small RNAs play important roles in many cellular processes. RnaG and RyhB sRNAs have been well studied in S. flexneri. Ssr1 sRNA, which could play...
some infectious agents such as early tuberculosis meningitis, nocardia or brucella may have an neutrophilic predominant inflammation. A eosinophilic predominant...
infections. It is effective against bacteria such as Moraxella catarrhalis, Brucella melitensis, Chlamydia pneumoniae, and Mycoplasma pneumoniae. Additionally...
regulating CD40L and BAFF signaling. TRAF3IP2 seems to be more specific to Brucella infections than other Gram-negative bacteria. In the study of Degos et...
small non-coding RNAs have been identified to play regulatory functions. Some can regulate the virulence genes. 150 unannotated sRNAs were identified by...
William A.; Walke, Henry (22 February 2019). "Notes from the Field: Human Brucella abortus RB51 Infections Caused by Consumption of Unpasteurized Domestic...
defence against bacteriophages. Single-cell transcriptomics using single-cell RNA-Seq gave the complete transcriptome of H. pylori which was published in 2010...
; Bower, William A.; Walke, Henry (2019). "Notes from the Field: Human Brucella abortus RB51 Infections Caused by Consumption of Unpasteurized Domestic...
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