Branched chain amino acid transaminase 1 information

BCAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ABJ, 2COG, 2COI, 2COJ
Identifiers
Aliases	BCAT1, BCATC, BCT1, ECA39, MECA39, PNAS121, PP18, branched chain amino acid transaminase 1
External IDs	OMIM: 113520; MGI: 104861; HomoloGene: 20320; GeneCards: BCAT1; OMA:BCAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	24,949,101 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	145,021,910 bp
RNA expression pattern
	Top expressed in
	tibia; ; synovial joint; ; retinal pigment epithelium; ; endothelial cell; ; lower lobe of lung; ; visceral pleura; ; pons; ; parietal pleura; ; germinal epithelium; ; stromal cell of endometrium;
	Top expressed in
	cumulus cell; ; facial motor nucleus; ; otic placode; ; medulla oblongata; ; medial vestibular nucleus; ; dorsal tegmental nucleus; ; pontine nuclei; ; inferior colliculus; ; habenula; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	transaminase activity; L-leucine transaminase activity; identical protein binding; catalytic activity; L-valine transaminase activity; L-isoleucine transaminase activity; transferase activity; branched-chain-amino-acid transaminase activity;
Cellular component	cytoplasm; mitochondrion; cytosol;
Biological process	metabolism; branched-chain amino acid biosynthetic process; cell population proliferation; cellular amino acid biosynthetic process; branched-chain amino acid metabolic process; leucine biosynthetic process; branched-chain amino acid catabolic process; valine biosynthetic process; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	586
	12035
	ENSG00000060982
	ENSMUSG00000030268
	P54687
	P24288
	NM_001178091; NM_001178092; NM_001178093; NM_001178094; NM_005504
	NM_001024468; NM_007532
	NP_001171562; NP_001171563; NP_001171564; NP_001171565; NP_005495
	NP_001019639; NP_031558
	Wikidata
View/Edit Human	View/Edit Mouse

Branched chain amino acid transaminase 1 is a protein that in humans is encoded by the BCAT1 gene.^[5] It is the first enzyme in the branched-chain amino acid (BCAA) degradation pathway and facilitates the reversible transamination of BCAAs and glutamate. BCAT1 resides in the cytoplasm, while its isoform, BCAT2, is found in the mitochondria.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000060982 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030268 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Branched chain amino acid transaminase 1". Retrieved 2016-04-21.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000060982 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030268 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Branched chain amino acid transaminase 1". Retrieved 2016-04-21.

Branched chain amino acid transaminase 1 information

and 15 Related for: Branched chain amino acid transaminase 1 information

Branched chain amino acid transaminase 1

Succinic acid

Chromosome 12

Acetolactate synthase

Urea cycle

Cahill cycle

Methionine transaminase

Purine nucleotide cycle

Valproate

Adenosine triphosphate

Metabolism

Hypervalinemia

Biochemistry

Leucine transaminase

Pyruvate dehydrogenase deficiency