Autoimmune polyendocrine syndrome type 2 information
See also: Autoimmune polyendocrine syndrome type 1
Medical condition
Autoimmune polyendocrine syndrome type 2
Other names
Schmidt's syndrome[1]
HLA-DQ2 one of the human leukocyte antigens genotypes responsible for this condition
Specialty
Endocrinology
Symptoms
Asplenia[1]
Risk factors
Human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4)[2]
Diagnostic method
Ultrasound, MRI[3]
Treatment
Thyroid-stimulating hormone[4]
Autoimmune polyendocrine syndrome type 2, a form of autoimmune polyendocrine syndrome also known as APS-II, or PAS II, is the most common form of the polyglandular failure syndromes.[2] PAS II is defined as the association between autoimmune Addison's disease and either autoimmune thyroid disease, type 1 diabetes, or both.[5] It is heterogeneous and has not been linked to one gene. Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). APS-II affects women to a greater degree than men.[2]
^ ab"Autoimmune polyglandular syndrome type 2 | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 2017-04-13. Retrieved 2017-04-12.
^ abcGreenspan, Francis S.; Gardner, David C. (2004). Basic clinical endocrinology. New York: McGraw-Hill. pp. 103. ISBN 978-0-07-140297-2.
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^Kahaly, George J. (2012-12-01). "Polyglandular Autoimmune Syndrome Type II". La Presse Médicale. 41 (12): e663–e670. doi:10.1016/j.lpm.2012.09.011. ISSN 0755-4982. PMID 23159534.
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