Ribbon diagram of a fragment of the membrane-binding domain of ankyrin R.[1]
Identifiers
Symbol
ANK1
Alt. symbols
AnkyrinR, Band2.1
NCBI gene
286
HGNC
492
OMIM
182900
PDB
1N11
RefSeq
NM_000037
UniProt
P16157
Other data
Locus
Chr. 8 p21.1-11.2
Search for
Structures
Swiss-model
Domains
InterPro
Ankyrin repeat
Identifiers
Symbol
Ank
Pfam
PF00023
InterPro
IPR002110
SMART
SM00248
PROSITE
PDOC50088
SCOP2
1awc / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
ANK2, neuronal
Identifiers
Symbol
ANK2
Alt. symbols
AnkyrinB
NCBI gene
287
HGNC
493
OMIM
106410
RefSeq
NM_001148
UniProt
Q01484
Other data
Locus
Chr. 4 q25-q27
Search for
Structures
Swiss-model
Domains
InterPro
ANK3, node of Ranvier
Identifiers
Symbol
ANK3
Alt. symbols
AnkyrinG
NCBI gene
288
HGNC
494
OMIM
600465
RefSeq
NM_020987
UniProt
Q12955
Other data
Locus
Chr. 10 q21
Search for
Structures
Swiss-model
Domains
InterPro
Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton.[2] Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. The name is derived from the Greek word ἄγκυρα (ankyra) for "anchor".
^PDB: 1N11; Michaely P, Tomchick DR, Machius M, Anderson RG (December 2002). "Crystal structure of a 12 ANK repeat stack from human ankyrinR". The EMBO Journal. 21 (23): 6387–96. doi:10.1093/emboj/cdf651. PMC 136955. PMID 12456646.
^Bennett V, Baines AJ (July 2001). "Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues". Physiological Reviews. 81 (3): 1353–92. doi:10.1152/physrev.2001.81.3.1353. PMID 11427698. S2CID 15307181.
Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. Ankyrins...
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DARPins (an acronym for designed ankyrin repeat proteins) are genetically engineered antibody mimetic proteins typically exhibiting highly specific and...
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Ankyrin repeat domain 33 is a protein that in humans is encoded by the ANKRD33 gene. GRCh38: Ensembl release 89: ENSG00000167612 – Ensembl, May 2017 GRCm38:...
KN motif and ankyrin repeat domains 4 is a protein that in humans is encoded by the KANK4 gene. GRCh38: Ensembl release 89: ENSG00000132854 – Ensembl...
interaction with this molecule enhances the surface expression of Na+ channels. Ankyrin has been found to be bounded to βIV spectrin, a spectrin isoform enriched...
Ankyrin repeat domain 22 is a protein that in humans is encoded by the ANKRD22 gene. GRCh38: Ensembl release 89: ENSG00000152766 – Ensembl, May 2017 GRCm38:...
NOTCH regulated ankyrin repeat protein is a protein that in humans is encoded by the NRARP gene. GRCh38: Ensembl release 89: ENSG00000198435 – Ensembl...
KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene. GRCh38: Ensembl release 89: ENSG00000197256...
Ankyrin Repeat And MYND Domain Containing 1 (ANKMY1) is a protein that in humans is encoded by the ANKMY1 gene. Known aliases of ANKMY1 include Zinc Finger...
Ankyrin repeat domain-containing protein 26 is a protein that in humans is encoded by the ANKRD26 gene. This protein has a function that is not currently...
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 gene. This gene encodes a...
Bank1 (B-cell scaffold protein with ankyrin repeats 1) is a protein-encoding human gene located on chromosome 4 (4q24. Adaptor protein that binds the...
Ankyrin repeat domain 11 is a protein that in humans is encoded by the ANKRD11 gene. This locus encodes an ankyrin repeat domain-containing protein. The...
Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene. This gene is a member of the muscle ankyrin repeat...
Ankyrin repeat domain-containing protein 1, or Cardiac ankyrin repeat protein is a protein that in humans is encoded by the ANKRD1 gene also known as CARP...
Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene. GRCh38: Ensembl release 89: ENSG00000105186 –...
(Harmonin-interacting, ankyrin repeat-containing protein). Ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. "Ankyrin repeat...
Hana; Karafiátová, Miroslava; et al. (11 February 2021). "A membrane-bound ankyrin repeat protein confers race-specific leaf rust disease resistance in wheat"...
surface area by preventing the membrane from collapsing (vesiculating). Ankyrin-based macromolecular complex – proteins linking the bilayer to the membrane...
and high-affinity target protein binding. They are derived from natural ankyrin repeat proteins. Repeat proteins are among the most common classes of binding...
POTE ankyrin domain family, member B is a protein in humans that is encoded by the POTEB gene.(Prostate, Ovary, Testes Expressed ankyrin domain family...
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