Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene.[4][5][6][7] It belongs to the motin family of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2) characterized by coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus.[6] Angiomotin is expressed predominantly in endothelial cells of capillaries as well as angiogenic tissues such as placenta and solid tumor.[8]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000041688 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Troyanovsky B, Levchenko T, Månsson G, Matvijenko O, Holmgren L (March 2001). "Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation". The Journal of Cell Biology. 152 (6): 1247–54. doi:10.1083/jcb.152.6.1247. PMC 2199208. PMID 11257124.
^Bratt A, Birot O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L (October 2005). "Angiomotin regulates endothelial cell-cell junctions and cell motility". The Journal of Biological Chemistry. 280 (41): 34859–69. doi:10.1074/jbc.M503915200. PMID 16043488.
^ abBratt A, Wilson WJ, Troyanovsky B, Aase K, Kessler R, Van Meir EG, Holmgren L, Meir EG (September 2002). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
^"Entrez Gene: AMOT angiomotin".
^Zetter BR (March 2001). "Hold that line. Angiomotin regulates endothelial cell motility". The Journal of Cell Biology. 152 (6): F35-6. doi:10.1083/jcb.152.6.F35. PMC 2199203. PMID 11257132.
of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2) characterized by coiled-coil domains...
endopeptidase.[which?] Angiostatin is known to bind many proteins, especially to angiomotin and endothelial cell surface ATP synthase but also integrins, annexin...
arm) of human chromosome 3: ADIPOQ: adiponectin AMOTL2: encoding protein Angiomotin-like protein 2 ARHGAP31: Rho GRPase activating protein 31 BCHE: butyrylcholinesterase...
Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene. Angiomotin is a protein that binds angiostatin, a circulating inhibitor...
Protein Interaction Partner Functional Effects AMOT, Angiomotin Binding sequesters YAP/TAZ in the cytoplasm, inhibiting their function AP-1, Activator...
for Transport or ESCRT pathway. HIV also uses the host proteins of the Angiomotin family to facilitate membrane envelopment prior to ESCRT- mediated budding...
O, Sinha I, Veitonmäki N, Aase K, Ernkvist M, Holmgren L (Oct 2005). "Angiomotin regulates endothelial cell-cell junctions and cell motility". The Journal...
as one of the interacting proteins. C7orf43 was found to interact with angiomotin-like protein 2 (AMOTL2), also known as Leman Coiled-Coil Protein (LCCP)...