Relative frequency of a variant of a gene at a particular locus in a population
Allele frequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a fraction or percentage.[1] Specifically, it is the fraction of all chromosomes in the population that carry that allele over the total population or sample size. Microevolution is the change in allele frequencies that occurs over time within a population.
Given the following:
A particular locus on a chromosome and a given allele at that locus
A population of N individuals with ploidy n, i.e. an individual carries n copies of each chromosome in their somatic cells (e.g. two chromosomes in the cells of diploid species)
The allele exists in i chromosomes in the population
then the allele frequency is the fraction of all the occurrences i of that allele and the total number of chromosome copies across the population, i/(nN).
The allele frequency is distinct from the genotype frequency, although they are related, and allele frequencies can be calculated from genotype frequencies.[1]
In population genetics, allele frequencies are used to describe the amount of variation at a particular locus or across multiple loci. When considering the ensemble of allele frequencies for many distinct loci, their distribution is called the allele frequency spectrum.
^ abGillespie, John H. (2004). Population genetics : a concise guide (2. ed.). Baltimore, Md.: The Johns Hopkins University Press. ISBN 978-0801880087.
Allelefrequency, or gene frequency, is the relative frequency of an allele (variant of a gene) at a particular locus in a population, expressed as a...
population genetics, the allelefrequency spectrum, sometimes called the site frequency spectrum, is the distribution of the allelefrequencies of a given set of...
Minor allelefrequency (MAF) is the frequency at which the second most common allele occurs in a given population. They play a surprising role in heritability...
allelic drift or the Wright effect, is the change in the frequency of an existing gene variant (allele) in a population due to random chance. Genetic drift...
heterozygote with two different "A" alleles.) The frequency of alleles in a diploid population can be used to predict the frequencies of the corresponding genotypes...
quantified by the frequency of alleles. Two fundamental calculations are central to population genetics: allelefrequencies and genotype frequencies. Genotype...
focuses only on the change in frequency of alleles within populations. The main processes influencing allelefrequencies are natural selection, genetic...
DNA (alleles) at different positions on the chromosome (loci) in a given population based on a comparison between the frequency at which two alleles are...
allelefrequency to shift toward the chosen extreme over time as allele ratios change from generation to generation. The advantageous extreme allele will...
be present only in the isolated population. Random fluctuation of allelefrequencies also produces genetic differentiation between populations. This process...
The AlleleFrequency Net Database (abbreviated AlFreD) is a database containing the allelefrequencies of immune genes and their corresponding alleles in...
gradient of allelefrequency in Europe, which shows that the highest allelefrequency occurred in the Nordic countries and lowest allelefrequency in southern...
the allelefrequencies of HLA-I and HLA-II genes for the European population has been compiled. In both cases the distribution of allelefrequencies reveals...
particular biochemical. Both of these branches of genetics use the frequencies of different alleles of a gene in breeding populations (gamodemes), and combine...
work described fitness as a function of allelefrequencies. Here, each dimension describes an allelefrequency at a different gene, and goes between 0...
also called genetic draft or the hitchhiking effect, is when an allele changes frequency not because it itself is under natural selection, but because it...
allele of the eye-color gene produces blue eyes and another allele of the eye-color gene produces brown eyes. allelefrequency The relative frequency...
subpopulations are in a Hardy–Weinberg equilibrium but have different allelefrequencies, the overall heterozygosity is reduced compared to if the whole population...
The frequency of one particular allele will become more or less prevalent relative to other forms of that gene. Variation disappears when a new allele reaches...
Microevolution is the change in allelefrequencies that occurs over time within a population. This change is due to four different processes: mutation...
false positive rate between 15-17% for SNPs, and also that the minor allelefrequency is greater than 10% for approximately 80% of the SNPs that are not...
population genetics, a fixed allele is an allele that is the only variant that exists for that gene in a population. A fixed allele is homozygous for all members...
PMID 17446367. S2CID 43290419. "Graphical display of AlleleFrequencies for Ala111Thr". AlleleFrequency Database. Archived from the original on 4 October...
Global Information