Adipose tissue expandability hypothesis information
Version of the hypothesis implicating failure to generate more adipocytes in tissue expandability
The adipose tissue expandability hypothesis posits that metabolic dysregulation that appears to be caused by excess weight, such as type 2 diabetes[1] and non-alcoholic fatty liver disease,[2] are triggered when an individual's capacity for storing excess calories in the subcutaneous adipose tissue is exceeded. Each individual's capacity to store excess energy varies, so the threshold at which an individual begins to experience metabolic disease is not well captured by methods such as body mass index or body fat percentage.[1] If a person has the ability to store a large amount of body fat without experiencing metabolic disturbance, this is known as metabolically healthy obesity.[3]
Although it was hypothesized that having a larger number of smaller adipocytes was correlated with the ability to store more fat, some evidence suggests the opposite—those with smaller adipocytes having a worse metabolic profile. The core factor, the inability to store excess fat in these cells, remains.[4]
^ abBosy‐Westphal, Anja; Müller, Manfred J. (March 2021). "Diagnosis of obesity based on body composition‐associated health risks—Time for a change in paradigm". Obesity Reviews. 22 (S2). doi:10.1111/obr.13190.
^Rabadán-Chávez, Griselda; Díaz de la Garza, Rocío I.; Jacobo-Velázquez, Daniel A. (December 2023). "White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1869 (8): 166853. doi:10.1016/j.bbadis.2023.166853.
^Porro, S.; Genchi, V. A.; Cignarelli, A.; Natalicchio, A.; Laviola, L.; Giorgino, F.; Perrini, S. (May 2021). "Dysmetabolic adipose tissue in obesity: morphological and functional characteristics of adipose stem cells and mature adipocytes in healthy and unhealthy obese subjects". Journal of Endocrinological Investigation. 44 (5): 921–941. doi:10.1007/s40618-020-01446-8.
^Richard, Allison J.; White, Ursula; Elks, Carrie M.; Stephens, Jacqueline M. (4 April 2020). "Adipose Tissue: Physiology to Metabolic Dysfunction". Endotext [Internet]. MDText.com, Inc.
and 28 Related for: Adipose tissue expandability hypothesis information
The adiposetissueexpandabilityhypothesis posits that metabolic dysregulation that appears to be caused by excess weight, such as type 2 diabetes and...
generated largely by abdominal subcutaneous fat. The later adiposetissueexpandabilityhypothesis hypothesizes that the cause of type 2 diabetes is not obesity...
PMID 26868089. Caprio S, Pierpont B, Kursawe R (March 2018). "The "adiposetissueexpandability" hypothesis: a potential mechanism for insulin resistance in obese...
composed of several adipose depots including mesenteric, epididymal white adiposetissue (EWAT), and perirenal fat. An excess of adipose visceral fat is known...
breast is composed of differing layers of tissue, predominantly two types: adiposetissue; and glandular tissue, which affects the lactation functions of...
1016/j.clnu.2013.10.003. PMID 24315622. Vidal-Puig A (2013). "Adiposetissueexpandability, lipotoxicity and the metabolic syndrome". Endocrinologia y Nutricion...
this hypothesis, as a response to the loss of the vertebrate mitochondrial uncoupling protein, UCP1. In mammals, UCP1 functions within brown adipose tissue...
multipotent, which can be found in adult tissues, for example, in the muscle, liver, bone marrow and adiposetissue. Mesenchymal stem cells usually function...
in more carbohydrates from grass seeds, and their brown adiposetissue significantly expands, creating an energy reserve for the next hibernation period...
shivering, and uncoupled oxidative metabolism, such as within brown adiposetissue. Only birds and mammals are extant universally endothermic groups of...
Scherer, Philipp E. (August 2011). "Paracrine and Endocrine Effects of AdiposeTissue on Cancer Development and Progression". Endocrine Reviews. 32 (4): 550–570...
origin and may differentiate into a variety of tissues. MSCs have been isolated from the placenta, adiposetissue, lung, bone marrow and blood, Wharton's jelly...
unpaired fins were acquired during evolution (e.g. additional dorsal fins, adipose fin). In some †Acanthodii ("spiny sharks"), one or more pairs of "intermediate"...
men may lead to abnormalities including frailty, accumulation of adipose fat tissue within the body, anxiety and depression, sexual performance issues...
available in the body. The second is non-shivering, which occurs in brown adiposetissue. Population studies have shown that the San tribe of Southern Africa...
primarily found in brown adiposetissue, or brown fat, and is responsible for non-shivering thermogenesis. Brown adiposetissue is found in mammals, and...
and epithelial cells can facilitate malignant cell growth. In breast adiposetissue, overexpression of leptin leads to increased cell proliferation and...
multi-compartment models, with compartments corresponding to predefined organs or tissues, with interconnections corresponding to blood or lymph flows (more rarely...
division. Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. Normally, the balance between proliferation...
to the embryo. Even later in the aphid's life, a second population of adipose cells are selected to become bacteriocytes. Bacteriocyte development has...
often found to have low amounts of ectopic fat (fat stored in tissues other than adiposetissue) despite having overall fat mass equivalent in weight to obese...
increases blood glucose levels by reducing glucose uptake in muscle and adiposetissue, decreasing protein synthesis, and increasing the breakdown of fats...
peripheral resistance to insulin, whereby the transport of fatty acids from adiposetissue to the liver is increased. Impairment or inhibition of receptor molecules...
the Relationship between Colorectal Cancer and Obesity: Is Visceral AdiposeTissue the Missing Link?". International Journal of Molecular Sciences. 23...
Breasts are made up of breast tissue, connective tissue, and adipose (fat) tissue. The amount of each of the three types of tissue varies from person to person...
intramuscular route due to a depot effect in which it is stored locally in adiposetissue, and can be administered once every 1 to 3 days. The half-life of intramuscular...
as bony structures and blood vessels. The hypodermis is made up of adiposetissue, which stores lipids and provides cushioning and insulation. The thickness...
very low-density lipoprotein (VLDL) particles which are taken up by adiposetissue, there to be stored as fats. The fat cells take up glucose through special...
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