Acquired generalized lipodystrophy (AGL), also known as Lawrence syndrome[1] and Lawrence–Seip syndrome,[1] is a rare skin condition that appears during childhood or adolescence, characterized by fat loss affecting large areas of the body, particularly the face, arms, and legs.[2]: 496 There are four types of lipodystrophy based on its onset and areas affected: acquired or inherited (congenital or familial), and generalized or partial. Both acquired or inherited lipodystrophy present as loss of adipose tissues, in the absence of nutritional deprivation. The near-total loss of subcutaneous adipose tissue is termed generalized lipodystrophy while the selective loss of adipose tissues is denoted as partial lipodystrophy.[3] Thus, as the name suggests, AGL is a near-total deficiency of adipose tissues in the body that is developed later in life. It is an extremely rare disease with only about 100 cases reported worldwide.[4][5] There are three main etiologies of AGL suspected: autoimmune, panniculitis-associated, or idiopathic.[6] After its onset, the disease progresses over a few days, weeks, months, or even in years.[6] Clinical presentations of AGL are similar to other lipodystrophies, including metabolic complications and hypoleptinemia.[6][5] Treatments are also similar and mainly supportive for symptomatic alleviation. Although HIV- or drug-induced lipodystrophy are types of acquired lipodystrophy, their origins are very specific and distinct and hence are usually not discussed with AGL (see HIV-associated lipodystrophy).
^ abRapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L., eds. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1. [page needed]
^James, William D.; Berger, Timothy G.; Elston, Dirk M., eds. (2006). Andrews' Diseases of the Skin: Clinical Dermatology (Ninth ed.). Saunders Elsevier. ISBN 978-0-7216-2921-6.
^Brown, Rebecca J.; Chan, Jean L.; Jaffe, Elaine S.; Cochran, Elaine; DePaoli, Alex M.; Gautier, Jean-Francois; Goujard, Cecile; Vigouroux, Corinne; Gorden, Phillip (2016-01-02). "Lymphoma in acquired generalized lipodystrophy". Leukemia & Lymphoma. 57 (1): 45–50. doi:10.3109/10428194.2015.1040015. PMC 4755279. PMID 25864863.
^Garg, Abhimanyu (2004-03-18). "Acquired and Inherited Lipodystrophies". New England Journal of Medicine. 350 (12): 1220–1234. doi:10.1056/nejmra025261. PMID 15028826.
Acquiredgeneralizedlipodystrophy (AGL), also known as Lawrence syndrome and Lawrence–Seip syndrome, is a rare skin condition that appears during childhood...
in addition to diet, in patients with congenital generalized or acquiredgeneralizedlipodystrophy. The most common side effects include hypoglycaemia...
tissue that lies between the dermis and underlying fascia. Acquiredgeneralizedlipodystrophy (Lawrence syndrome, Lawrence–Seip syndrome) Adiposis dolorosa...
congenital or acquiredgeneralizedlipodystrophy. In Europe based on EMA, metreleptin should be used in addition to diet to treat lipodystrophy, where patients...
lipid. Seipin mutations have been associated with congenital generalizedlipodystrophy (see below), and mutations in an N-glycosylation motif links seipin...
in addition to diet, in patients with congenital generalized or acquiredgeneralizedlipodystrophy. Metraleptin was originally developed at Amylin Pharmaceuticals...
Mutations in this gene have been associated with congenital generalizedlipodystrophy, a disease characterized by a near absence of adipose tissue and...
range from mandibuloacral dysplasia, progeroid appearance, and generalizedlipodystrophy to infant-lethal restrictive dermopathy.[citation needed] In the...
involuntary muscle contractions (fasciculations, myotonia, or spasticity). In lipodystrophy, an abnormal deficit of subcutaneous fat accentuates the appearance...
accompanied by distinct symptoms of the syndrome, such as central obesity, lipodystrophy, moon face, sweating, hirsutism and anxiety. Neuroendocrine tumors are...
Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome". Proceedings of the National Academy of Sciences of the United...
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