Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene.[5]
Functional studies indicate that ATG9A plays a role in autophagy.[6][7] and other non-autophagy membrane remodeling processes such as plasma membrane repair.[8] Enzymatically, it is a lipid scramblase.[6][7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000198925 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033124 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)".
^ abMaeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). "Structure, lipid scrambling activity and role in autophagosome formation of ATG9A". Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC 7718406. PMID 33106659.
^ abMatoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID 33106658. S2CID 225081989.
^ abClaude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). "ATG9A protects the plasma membrane from programmed and incidental permeabilization". Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN 1465-7392. PMC 8276549. PMID 34257406.
9A is a protein that in humans is encoded by the ATG9A gene. Functional studies indicate that ATG9A plays a role in autophagy. and other non-autophagy...
Yamamoto N, Kawai T, Ishii K, Takeuchi O, Yoshimori T, Akira S (Dec 2009). "Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune...
Autophagosomal phagophores expand through lipid transfer processes dependent on ATG9A and ATG2A/B whereas mATG8s play multiple roles, one of which is to serve...
autophagy-related protein 9a (ATG9A), a transmembrane protein that facilitates the interaction between LC3 and autophagosomes. Disruption in ATG9A trafficking by the...
activity, 14-3-3ζ activates autophagy under hypoxic conditions by binding ATG9A, while it prevents autophagy under hyperglycemic conditions by binding Vps34...