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Infobox references
Chemical compound
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, better known as AMPA, is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.[1]
There are several types of glutamatergic ion channels in the central nervous system including AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions.[2] AMPA generates fast excitatory postsynaptic potentials (EPSP).[1] AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV.
AMPA was first synthesized, along with several other ibotenic acid derivatives, by Krogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from aspartate sensitive receptors.[3]
^ abPurves, Dale; George J. Augustine; David Fitzpatrick; William C. Hall; Anthony-Samuel LaMantia; James O. McNamara & Leonard E. White (2008). Neuroscience (4th ed.). Sinauer Associates. pp. 128–33. ISBN 978-0-87893-697-7.
^Dinh, L; Nguyen T; Salgado H; Atzori M (2009). "Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat". Neurochem Res. 34 (11): 1896–906. doi:10.1007/s11064-009-9966-z. PMID 19357950. S2CID 25255160.
^Krogsgaard-Larsen, P; Honore T; Hansen JJ; Curtis DR; Lodge D (1980). "New class of glutamate agonist structurally related to ibotenic acid". Nature. 284 (5751): 64–66. Bibcode:1980Natur.284...64K. doi:10.1038/284064a0. PMID 6101908. S2CID 4252428.
l-4-isoxazolepropionic acid, better known as AMPA, is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the...
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane...
Ampa Skywalk is a shopping mall in Chennai, India. With three floors of retail space, it has outlets for major clothing and apparel brands, a seven-screen...
glutamatergic protein receptors such as NMDA and AMPA receptors. Post-synaptic AMPA receptor: AMPA Receptors are trans-membrane protein ionotropic receptors...
South West Ampa (SWA) gas field, also known as Ampa Field or Southwest Ampa, is a conventional gas field 13 kilometres (8.1 mi) off Kuala Belait and near...
presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It has been awarded since the 1st Academy Awards to an actress who has...
presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It has been awarded since the 1st Academy Awards to an actor who has delivered...
Ampakines or AMPAkines are a subgroup of AMPA receptor positive allosteric modulators with a benzamide or closely related chemical structure. They are...
presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It has been awarded since the 9th Academy Awards to an actress who has...
presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS). It has been awarded since the 9th Academy Awards to an actor who has delivered...
Jalan Ampas is a street near Balestier Road in Singapore where the movie studios Malay Film Productions and Shaw Brothers were located. The name Jalan...
NMDA-type glutamate receptors but no AMPA-type glutamate receptors. These synapses are named "silent" because normal AMPA receptor-mediated signaling is not...
Aminomethylphosphonic acid (AMPA) is a weak organic acid with a phosphonic acid group. AMPA apparently can be used as biocide and pesticide. AMPA is also used in...
glutamate receptors: AMPA and kainate receptors. Willardiine analogs have been developed that have different binding affinities for the AMPA and kainate receptors...
classified as a non-NMDA-type receptor, along with the AMPA receptor. KARs are less understood than AMPA and NMDA receptors, the other ionotropic glutamate...
AMPA receptor positive allosteric modulators are positive allosteric modulators (PAMs) of the AMPA receptor (AMPR), a type of ionotropic glutamate receptor...
Sciences (AMPAS). Retrieved August 27, 2013. "The 14th Academy Awards (1942) Nominees and Winners". Academy of Motion Picture Arts and Sciences (AMPAS). Retrieved...
Feature was first awarded in 2002 for films released in 2001. The entire AMPAS membership has been eligible to choose the winner since the award's inception...
PSD-95 that increases synaptic capacity for AMPA receptors. This is what leads to a long-term increase in AMPA receptors and thus synaptic strength and plasticity...
ketogenic diet. Decanoic acid and the AMPA receptor antagonist drug perampanel act at separate sites on the AMPA receptor, and so it is possible that they...
antiepileptic drug in the class of selective non-competitive antagonist of AMPA receptors. The drug label has a black box warning that the drug may cause...
modulators of the AMPA receptor. Racetams are understood to work by allosterically modulating glutamate receptors, specifically AMPA receptors, leading...
presented annually by the Academy of Motion Picture Arts and Sciences (AMPAS) since the awards debuted in 1929. This award goes to the producers of the...