regulation of type I interferon-mediated signaling pathway
defense response to virus
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6059
24015
Ensembl
ENSG00000164163
ENSMUSG00000058355
UniProt
P61221
P61222
RefSeq (mRNA)
NM_002940 NM_001040876
NM_015751
RefSeq (protein)
NP_001035809 NP_002931
NP_056566
Location (UCSC)
Chr 4: 145.1 – 145.13 Mb
Chr 8: 80.41 – 80.44 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene.
ABCE1 is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily.[5]
ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L,[6] and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis.[7]
ABCE1 is an essential and highly conserved protein that is required for both eukaryotic translation initiation as well as ribosome biogenesis. The most studied homologues are Rli1p in yeast and Pixie in Drosophila.
^ abcGRCh38: Ensembl release 89: ENSG00000164163 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058355 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 [ Homo sapiens ]". Retrieved 14 March 2013.
^"P61221 (ABCE1_HUMAN)".
^Tian Y, Han X, Tian DL (October 2012). "The biological regulation of ABCE1". IUBMB Life. 64 (10): 795–800. doi:10.1002/iub.1071. PMID 23008114. S2CID 21490502.
sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene. ABCE1 is an ATPase that is...
encode for trans-membrane domains. ABCE consists of only one member, OABP or ABCE1, which is known to recognize certain oligodendrocytes produced in response...
renewable energy and based in Berlin, Germany RLI (gene), also known as ABCE1, a protein required for translation initiation in eukaryotes RLi, an abbreviation...
and in meiotic cell division. In yeasts, the Dom34-Hbs1 complex (with ABCE1) that it forms is responsible for reactivating ribosomes and for recovering...
ribosomes. It does not have GGQ. The recycling and breakup is mediated by ABCE1. Capecchi MR (September 1967). "Polypeptide chain termination in vitro:...
with many leaderless mRNAs probably initiated by scanning. The process of ABCE1 ATPase-based recycling is also shared with eukaryotes. Being a prokaryote...
Global Information
