ABCA8 information

ABCA8
Identifiers
Aliases	ABCA8, ATP binding cassette subfamily A member 8
External IDs	OMIM: 612505; MGI: 1351668; HomoloGene: 56029; GeneCards: ABCA8; OMA:ABCA8 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	68,955,392 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	109,886,671 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; parietal pleura; ; pericardium; ; tibial nerve; ; cardiac muscle tissue of right atrium; ; germinal epithelium; ; corpus callosum; ; sural nerve; ; vena cava;
	Top expressed in
	lumbar spinal ganglion; ; muscle of thigh; ; liver; ; neural layer of retina; ; left lobe of liver; ; dentate gyrus of hippocampal formation granule cell; ; esophagus; ; extraocular muscle; ; upper arm; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; ABC-type xenobiotic transporter activity; ATPase-coupled transmembrane transporter activity; lipid transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; mitochondrial inner membrane; intracellular membrane-bounded organelle;
Biological process	lipid transport; xenobiotic transport; xenobiotic transmembrane transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	10351
	27404
	ENSG00000141338
	ENSMUSG00000020620
	O94911
	Q8K440
	NM_001288985; NM_001288986; NM_007168; NM_001375771; NM_001375772
	NM_013851; NM_001362749
	NP_001275914; NP_001275915; NP_009099; NP_001362700; NP_001362701
	NP_038879; NP_001349678
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene.^[5]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141338 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020620 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141338 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020620 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8".

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