ZHX2 information

ZHX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DMP, 3NAU
Identifiers
Aliases	ZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDs	OMIM: 609185; MGI: 2683087; HomoloGene: 8968; GeneCards: ZHX2; OMA:ZHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	122,974,510 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	57,703,228 bp
RNA expression pattern
	Top expressed in
	superficial temporal artery; ; dorsal motor nucleus of vagus nerve; ; saphenous vein; ; Skeletal muscle tissue of rectus abdominis; ; inferior olivary nucleus; ; internal globus pallidus; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; caput epididymis; ; lactiferous duct;
	Top expressed in
	knee joint; ; triceps brachii muscle; ; vastus lateralis muscle; ; otolith organ; ; temporal muscle; ; utricle; ; skeletal muscle tissue; ; medial head of gastrocnemius muscle; ; granulocyte; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; protein homodimerization activity; transcription corepressor activity; metal ion binding; identical protein binding; protein heterodimerization activity; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol; plasma membrane;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; mRNA catabolic process; negative regulation of neuron differentiation; somatic stem cell population maintenance; transcription, DNA-templated; retinal bipolar neuron differentiation; nervous system development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	22882
	387609
	ENSG00000178764
	ENSMUSG00000071757
	Q9Y6X8
	Q8C0C0
	NM_014943; NM_001362797
	NM_199449
	NP_055758; NP_001349726
	NP_955520
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.^[5]^[6]^[7]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178764 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071757 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.
^ ^a ^b "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178764 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071757 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid12741956-6] Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K (Jul 2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor". Biochem J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956.

[entrez-7] "Entrez Gene: ZHX2 zinc fingers and homeoboxes 2".

ZHX2 information

and 5 Related for: ZHX2 information

ZHX2

List of human transcription factors

Chromosome 8

Human identical sequence

ZHX3