Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.[3][4]
This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.[4]
Humans express a single ZFY gene with two splice variants, while mice express two paralogous copies, Zfy1 and Zfy2.[5] During spermatogenesis, wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, apoptosis, at the mid-pachytene checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.[5]
In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.[6]
Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000067646 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Müller G, Schempp W (April 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060. S2CID 27908892.
finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. This gene encodes a zinc finger-containing protein...
chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of the krüppel C2H2-type zinc-finger protein family...
X paralog Note SRY SOX3 Sex-determining region. This is the p arm [Yp]. ZFY ZFX Zinc finger. RPS4Y1 RPS4X Ribosomal protein S4. AMELY AMELX Amelogenin...
1938 when they were merged into station ZFY under the British Guiana United Broadcasting Co Ltd. In 1949, ZFY secured a medium wave transmitter. In 1950...
Brent S.; Karl, Stephen A. (2007-05-01). "Sexing Pinnipeds with ZFX and ZFY Loci". Journal of Heredity. 98 (3): 280–285. doi:10.1093/jhered/esm023. ISSN 0022-1503...
Brent S.; Karl, Stephen A. (2007-05-01). "Sexing Pinnipeds with ZFX and ZFY Loci". Journal of Heredity. 98 (3): 280–285. doi:10.1093/jhered/esm023. ISSN 0022-1503...
ENSG00000005889 C2H2 ZF Known motif – In vivo/Misc source [1,090] VVSVSBNBBAGGCCBVGSH ZFY ENSG00000067646 C2H2 ZF Inferred motif from similar protein – In vivo/Misc...
student Andrew Sinclair, was instrumental in providing evidence that the ZFY gene, at the time proposed to be the testis-determining factor, was not required...
Black. Curtis C, Stewart BS, Karl SA (2007). "Sexing pinnipeds with ZFX and ZFY loci". Journal of Heredity. 98 (3): 286–290. doi:10.1093/jhered/esm023. PMID 17548861...
demonstrated that activity of mouse homologues of the existing candidate, ZFY, was not consistent with a role in sex determination. Lovell-Badge's team...
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