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ZFY information


ZFY
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesZFY, ZNF911, zinc finger protein, Y-linked, zinc finger protein Y-linked
External IDsOMIM: 490000; HomoloGene: 88465; GeneCards: ZFY; OMA:ZFY - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145275
NM_001145276
NM_003411

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr Y: 2.94 – 2.98 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome.[3][4]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.[4]

Humans express a single ZFY gene with two splice variants, while mice express two paralogous copies, Zfy1 and Zfy2.[5] During spermatogenesis, wrongful expression of either Zfy1 or Zfy2 results in programmed cell death, apoptosis, at the mid-pachytene checkpoint. In mice, Zfy genes are necessary for meiotic sex chromosome inactivation (MSCI). In Zfy knockout spermatocytes, sex chromosomes are incorrectly silenced. Thus, Zfy performs three functions at the mid-pachytene checkpoint: (1) promote MSCI, (2) monitor MSCI progress, and (3) execute cells, via apoptosis, that fail to undergo MSCI.[5]

In humans, ZFY is most broadly expresses in the testis and prostate. However, 20 other tissues also express ZFY, such as esophagus, urinary bladder, bone marrow, small intestine, appendix and gall bladder.[6]

Disorders associated with the ZFY gene include campomelic dysplasia, cystadenofibroma, and Frasier syndrome.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000067646 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Müller G, Schempp W (April 1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization". Human Genetics. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060. S2CID 27908892.
  4. ^ a b "Entrez Gene: ZFY zinc finger protein, Y-linked".
  5. ^ a b Vernet N, Mahadevaiah SK, de Rooij DG, Burgoyne PS, Ellis PJ (December 2016). "Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes". Human Molecular Genetics. 25 (24): 5300–5310. doi:10.1093/hmg/ddw344. PMC 5418838. PMID 27742779.
  6. ^ "ZFY Gene". GeneCards. Retrieved 2019-04-15.
  7. ^ "MalaCards: Search Human Diseases - ZFY". Mala Cards. Retrieved 2019-04-15.

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ZFY

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finger Y-chromosomal protein is a protein that in humans is encoded by the ZFY gene of the Y chromosome. This gene encodes a zinc finger-containing protein...

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ZFX

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chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of the krüppel C2H2-type zinc-finger protein family...

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Radio in Guyana

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1938 when they were merged into station ZFY under the British Guiana United Broadcasting Co Ltd. In 1949, ZFY secured a medium wave transmitter. In 1950...

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Y chromosome

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X paralog Note SRY SOX3 Sex-determining region. This is the p arm [Yp]. ZFY ZFX Zinc finger. RPS4Y1 RPS4X Ribosomal protein S4. AMELY AMELX Amelogenin...

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Crabeater seal

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Brent S.; Karl, Stephen A. (2007-05-01). "Sexing Pinnipeds with ZFX and ZFY Loci". Journal of Heredity. 98 (3): 280–285. doi:10.1093/jhered/esm023. ISSN 0022-1503...

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Ross seal

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Brent S.; Karl, Stephen A. (2007-05-01). "Sexing Pinnipeds with ZFX and ZFY Loci". Journal of Heredity. 98 (3): 280–285. doi:10.1093/jhered/esm023. ISSN 0022-1503...

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Y linkage

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protein), IL3RAY (interleukin-3 receptor), SRY (sex-determining region), ZFY (zinc finger protein), PRKY (protein kinase, Y-linked), AMELY (amelogenin...

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Weddell seal

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Black. Curtis C, Stewart BS, Karl SA (2007). "Sexing pinnipeds with ZFX and ZFY loci". Journal of Heredity. 98 (3): 286–290. doi:10.1093/jhered/esm023. PMID 17548861...

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List of human transcription factors

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ENSG00000005889 C2H2 ZF Known motif – In vivo/Misc source [1,090] VVSVSBNBBAGGCCBVGSH ZFY ENSG00000067646 C2H2 ZF Inferred motif from similar protein – In vivo/Misc...

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Apyrauna

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identifiers Apyrauna Wikidata: Q4782345 Wikispecies: Apyrauna BioLib: 282239 CoL: ZFY EoL: 10105 GBIF: 1113684 IRMNG: 1042755 Open Tree of Life: 3383402...

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Timeline of the introduction of radio in countries

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(EAJ-43 R. Club Tenerife, Santa Cruz) 1935 British Guiana (VP3BG Georgetown > ZFY), Dutch Guiana (AVROS, Paramaribo), Ethiopia (R. Addis Ababa), Fiji (ZJV...

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Jenny Graves

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student Andrew Sinclair, was instrumental in providing evidence that the ZFY gene, at the time proposed to be the testis-determining factor, was not required...

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Tetratricopeptide repeat 39A

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Fork head domain factors FOXK2 54 70 - X-linked zinc finger protein ZFX and ZFY 118 128 - E2F transcription factor 4, p107/p130-binding protein 475 491 -...

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Peter Koopman

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demonstrated that activity of mouse homologues of the existing candidate, ZFY, was not consistent with a role in sex determination. Lovell-Badge's team...

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"Give Me Some" (3:12) "Saturday Night" (2:16) "Space Between Bodies" (2007) "Space between bodies" video: https://www.youtube.com/watch?v=fTpCTnZFyWA...

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