ZBTB33 information

ZBTB33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LT7, 3FKC, 3M4T, 3M8V, 4F6M, 4F6N
Identifiers
Aliases	ZBTB33, ZNF-kaiso, ZNF348, zinc finger and BTB domain containing 33
External IDs	OMIM: 300329; MGI: 1927290; HomoloGene: 4931; GeneCards: ZBTB33; OMA:ZBTB33 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	120,258,398 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	37,285,923 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; Brodmann area 23; ; corpus epididymis; ; bronchial epithelial cell; ; middle temporal gyrus; ; trabecular bone; ; palpebral conjunctiva; ; germinal epithelium; ; ganglionic eminence;
	Top expressed in
	medial ganglionic eminence; ; hair follicle; ; condyle; ; pineal gland; ; trigeminal ganglion; ; parotid gland; ; fossa; ; Region I of hippocampus proper; ; conjunctival fornix; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyl-CpG binding; sequence-specific DNA binding; DNA binding; protein binding; metal ion binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	plasma membrane; nucleolus; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	intracellular signal transduction; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; Wnt signaling pathway; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10009
	56805
	ENSG00000177485
	ENSMUSG00000048047
	Q86T24
	Q8BN78
	NM_006777; NM_001184742
	NM_001079513; NM_020256
	NP_001171671; NP_006768
	NP_001072981; NP_064652
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene.^[5] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]

NAMED by Dr.Juliet Daniel's, the KAISO gene was named after 'calypso' music popular in the Caribbeans, Trinidad & Tobago, e.t.c.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177485 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33".
^ "ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-03-22.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177485 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048047 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ZBTB33 zinc finger and BTB domain containing 33".

[6] "ZBTB33 zinc finger and BTB domain containing 33 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-03-22.

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