Winchester syndrome or Torg-Winchester syndrome or Multicentric Osteolysis, Nodulosis, and Arthropathy
Other names
Torg-Winchester syndrome[1] Multicentric Osteolysis, Nodulosis, and Arthropathy[2]
Matrix Metalloproteinase 2
Winchester syndrome is a rare hereditary connective tissue disease described in 1969,[3] of which the main characteristics are short stature, marked contractures of joints, opacities in the cornea, coarse facial features, dissolution of the carpal and tarsal bones (in the hands and feet, respectively), and osteoporosis. Winchester syndrome was once considered to be related to a similar condition, multicentric osteolysis, nodulosis, and arthropathy (MONA).[4][5] However, it was discovered that the two are caused by mutations found in different genes; however they mostly produce the same phenotype or clinical picture.[4] Appearances resemble rheumatoid arthritis. Increased uronic acid is demonstrated in cultured fibroblasts from the skin and to a lesser degree in both parents. Despite initial tests not showing increased mucopolysaccharide excretion, the disease was regarded as a mucopolysaccharidosis.[3] Winchester syndrome is thought to be inherited as an autosomal recessive trait.
^RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Torg Winchester syndrome". www.orpha.net. Retrieved 27 April 2019.{{cite web}}: CS1 maint: numeric names: authors list (link)
Winchestersyndrome is a rare hereditary connective tissue disease described in 1969, of which the main characteristics are short stature, marked contractures...
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in the MMP2 gene are associated with Torg-Winchestersyndrome, multicentric osteolysis, arthritis syndrome, and possibly keloids. Activity of MMP-2 relative...
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Harold Francis Falls (November 25, 1909 in Winchester, Indiana – May 27, 2006 in Brighton, Michigan) was an American ophthalmologist and geneticist. He...
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boys. Fagging was a fully established system at St Paul's, Eton, and Winchester in the sixteenth century. Fagging carried with it well-defined rights...
patent, and it seems likely that most schools were immediately replaced. Winchester College founded by Bishop William of Wykeham in 1382 and Oswestry School...
ISBN 978-0-2034-3950-0. Winchester Museums Service (4 December 2009). "Summary of Hyde Community Archaeology Project (completed in 1999)". Winchester Council. Archived...
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