Wender Taxol total synthesis overview from raw material perspective
Wender Taxol total synthesis in organic chemistry describes a Taxol total synthesis (one of six to date) by the group of Paul Wender at Stanford University published in 1997.[1][2] This synthesis has much in common with the Holton Taxol total synthesis in that it is a linear synthesis starting from a naturally occurring compound with ring construction in the order A,B,C,D. The Wender effort is shorter by approximately 10 steps.
Raw materials for the preparation of Taxol by this route include verbenone, prenyl bromine, allyl bromide, propiolic acid, Gilman reagent, and Eschenmoser's salt.
^The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor Paul A. Wender et al.J. Am. Chem. Soc.; 1997; 119(11) pp 2755 - 2756; (Communication) doi:10.1021/ja9635387
^The Pinene Path to Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol Wender, P. A. et al. J. Am. Chem. Soc.; (Communication); 1997; 119(11); 2757-2758. doi:10.1021/ja963539z
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