The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins.[1] WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy,[1] and contain a conserved motif for interaction with phospholipids.[2]
Members of this family include:
Protein
Gene
Aliases
Yeast
WIPI-1
WIPI1
WIPI49, FLJ10055
Atg18
WIPI-2
WIPI2
Svp1a, DKFZP434J154 WIPI49-like protein 2
Atg21
WIPI-3
WDR45L
628 protein, WIPI49-like protein
WIPI-4
WDR45
JM5 protein, WDRX1
^ abProikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.
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WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) is a protein that in humans is encoded by the WDR45 gene. Mutations in this gene cause...
phosphoinositide-interacting protein 3 (WIPI-3), also known as WD repeat-containing protein 45-like is a protein that in humans is encoded by the gene. WIPI-3 is a member...
for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller...
docking point for proteins harboring a PtdIns(3)P binding motif. WIPI2, a PtdIns(3)P binding protein of the WIPI (WD-repeat protein interacting with phosphoinositides)...
the next repeat to form the 3D blade structure. WD40-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions...
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