mRNA cleavage and polyadenylation specificity factor complex
collagen
nucleus
fibrillar center
nucleoplasm
Biological process
mRNA processing
mRNA cleavage
postreplication repair
spermatogenesis
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
mRNA export from nucleus
mRNA 3'-end processing
mRNA polyadenylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
55339
74320
Ensembl
ENSG00000136709
ENSMUSG00000024400
UniProt
Q9C0J8
Q8K4P0
RefSeq (mRNA)
NM_001006622 NM_001006623 NM_018383
NM_001170966 NM_001170967 NM_001170970 NM_028866
RefSeq (protein)
NP_001006623 NP_001006624 NP_060853
NP_001164437 NP_001164438 NP_001164441 NP_083142
Location (UCSC)
Chr 2: 127.7 – 127.81 Mb
Chr 18: 31.94 – 32.04 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.[5][6]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000136709 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024400 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ito S, Sakai A, Nomura T, Miki Y, Ouchida M, Sasaki J, Shimizu K (Feb 2001). "A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner". Biochem Biophys Res Commun. 280 (3): 656–63. doi:10.1006/bbrc.2000.4163. PMID 11162572.
repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene. This gene encodes a member of the WD repeat protein family. WD repeats...
(CPSF1), CPSF-100 (CPSF2), CPSF-73 (CPSF3), and CPSF-30 (CPSF4) kDa subunits, WDR33 and Fip1 (FIP1L1). The subunits form two components: mammalian polyadenylation...
CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus. GRCh38: Ensembl release 89: ENSG00000071894...