A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. Viruses are infectious agents that can replicate in their host organism, however virosomes do not replicate. The properties that virosomes share with viruses are based on their structure; virosomes are essentially safely modified viral envelopes that contain the phospholipid membrane and surface glycoproteins. As a drug or vaccine delivery mechanism they are biologically compatible with many host organisms and are also biodegradable. The use of reconstituted virally derived proteins in the formation of the virosome allows for the utilization of what would otherwise be the immunogenic properties of a live-attenuated virus, but is instead a safely killed virus.[1] A safely killed virus can serve as a promising vector because it won't cause infection and the viral structure allows the virosome to recognize specific components of its target cells.[citation needed]
^Kapoor, D.; Vyas, R. B.; Lad, C.; Patel, M. (2013-09-14). "A Multipurpose and Novel Carrier for Drug Delivery and Targeting - Virosomes". Journal of Drug Delivery and Therapeutics. 3 (5): 143–147. doi:10.22270/jddt.v3i5.627. ISSN 2250-1177.
A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus...
A drug carrier or drug vehicle is a substrate used in the process of drug delivery which serves to improve the selectivity, effectiveness, and/or safety...
known adjuvants in widespread use, including aluminium salts, oils and virosomes. Adjuvants in immunology are often used to modify or augment the effects...
Vaccine Polio vaccine List of vaccine ingredients List of vaccine topics Virosome Das, Razib; Mishra, Pravin; Jha, Rajesh (2021-11-11). "In ovo Feeding as...
"Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP". PLOS ONE...
under the brand names HAVpur and VIROHEP-A. This vaccine consists of virosomes, artificial particles composed of synthetic lipids and influenza proteins...
been some hybrid methods developed that combine two or more techniques. Virosomes are one example; they combine liposomes with an inactivated HIV or influenza...
List of vaccine ingredients List of vaccine topics Reverse vaccinology Virosome Immunity Keller H, Glueck R, Wegmann A et al. Immunogenicity of a New,...
vaccines. Immunotherapy List of vaccine ingredients List of vaccine topics Virosome "Selecting Viruses for the Seasonal Influenza Vaccine". Cdc.gov. Retrieved...
developing a pre-clinical preventative vaccine for HSV 1 and 2 using its virosome technology. There has not been any recent announcement by the company regarding...
cytoplasm and utilises a specific virus-made structure for replication, the 'virosome'. Furthermore, gene expression is divided into three phases: early, intermediate...
infected host.[citation needed] Cancer Gene therapy Oncolytic virus Vector Virosome, using modified viruses for drug delivery Dog parasite press article Stephen...
ribosomes necessary for replication. Virosomes are often surrounded by a membrane; the membrane surrounding the virosome contained in the infected cells in...
with central nervous system disorders. E5R protein from Chordopoxvirus virosomes, which is found in cytoplasmic sites of viral DNA replication. Several...
sialic acid residues on the red blood cell surface to induce fusion . Virosomes, which consist of viral membrane components reconstituted into liposomes...
focus on nanoparticle-based novel delivery systems including dendrimers/virosomes for gene packaging and liposomes, niosomes, microspheres and solid core...
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