In molecular biology, the BEN domain is a protein domain which is found in diverse proteins including:
SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of prostaglandin A2 (PGA2) induced growth arrest.[1][2]
NACC1, a novel member of the POZ/BTB (Pox virus and Zinc finger/Broad complex, Tramtrack and Bric-a-brac), but which varies from other proteins of this class in that it lacks the characteristic DNA-binding motif.[3]
Mod(mdg4) isoform C, the modifier of the mdg4 locus in Drosophila melanogaster (Fruit fly), where mdg4 encodes chromatin proteins which are involved in position effect variegation, establishment of chromatin boundaries, nerve path finding, meiotic chromosome pairing and apoptosis.[4] Trans-splicing of Mod(mdg4) produces at least 26 transcripts.
BEND2, a protein of unknown function, that is predicted to be involved in chromatin modification and has been associated clinically with central nervous system disorders.
E5R protein from Chordopoxvirus virosomes, which is found in cytoplasmic sites of viral DNA replication.[5]
Several proteins of polydnaviruses.
The BEN domain is predicted to function as an adaptor for the higher-order structuring of chromatin, and recruitment of chromatin modifying factors in transcriptional regulation. It has been suggested to mediate protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role in the organisation of viral DNA during replication or transcription. They are generally linked to other globular domains with functions related to transcriptional regulation and chromatin structure, such as BTB, C4DM, and C2H2 fingers.[6]
This domain is predicted to form an all-alpha fold with four conserved helices. Its conservation pattern revealed several conserved residues, most of which have hydrophobic side-chains and are likely to stabilize the fold through helix-helix packing.[6] First human BEN domain (BEND3)structure is solved together with TPR (ERCC6L)domain and Stimulates the ERCC6L translocase and ATPase activities.[7]
^Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (October 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology. 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMC 1265755. PMID 16166625.
^Pavithra L, Rampalli S, Sinha S, Sreenath K, Pestell RG, Chattopadhyay S (2007). "Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR". Nucleic Acids Research. 35 (18): 6004–16. doi:10.1093/nar/gkm649. PMC 2094063. PMID 17726044.
^Mackler S, Pacchioni A, Degnan R, Homan Y, Conti AC, Kalivas P, Blendy JA (February 2008). "Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response". Behavioural Brain Research. 187 (1): 48–55. doi:10.1016/j.bbr.2007.08.036. PMC 2248375. PMID 17945361.
^Krauss V, Dorn R (April 2004). "Evolution of the trans-splicing Drosophila locus mod(mdg4) in several species of Diptera and Lepidoptera". Gene. 331: 165–76. doi:10.1016/j.gene.2004.02.019. PMID 15094203.
^Murcia-Nicolas A, Bolbach G, Blais JC, Beaud G (January 1999). "Identification by mass spectroscopy of three major early proteins associated with virosomes in vaccinia virus-infected cells". Virus Research. 59 (1): 1–12. doi:10.1016/S0168-1702(98)00114-2. PMID 10854161.
^ abAbhiman S, Iyer LM, Aravind L (February 2008). "BEN: a novel domain in chromatin factors and DNA viral proteins". Bioinformatics. 24 (4): 458–61. doi:10.1093/bioinformatics/btn007. PMC 2477736. PMID 18203771.
^Pitchai, Ganesha P.; Kaulich, Manuel; Bizard, Anna H.; Mesa, Pablo; Yao, Qi; Sarlos, Kata; Streicher, Werner W.; Nigg, Erich A.; Montoya, Guillermo; Hickson, Ian D. (2017-11-02). "A novel TPR–BEN domain interaction mediates PICH–BEND3 association". Nucleic Acids Research. 45 (19): 11413–11424. doi:10.1093/nar/gkx792. PMC 5737856.
In molecular biology, the BENdomain is a protein domain which is found in diverse proteins including: SMAR1 (Scaffold/Matrix attachment region-binding...
BENdomain containing 4 is a protein that in humans is encoded by the BEND4 gene. GRCh38: Ensembl release 89: ENSG00000188848 – Ensembl, May 2017 GRCm38:...
The Domain Name System (DNS) is a hierarchical and distributed name service that provides a naming system for computers, services, and other resources...
revealed in 2014 when WGCZ brought a Uniform Domain-Name Dispute-Resolution Policy case against a similar domain in 2014. In March 2016, The Next Web identified...
2023. Retrieved June 15, 2023. Schoon, Ben (September 17, 2023). "Google Domains has stopped selling new domains". 9to5Google. Retrieved September 19,...
Most Expensive Domain Names". Retrieved 1 May 2013. Jackson, Nicholas. "Domain Name Prices - 01." The Atlantic. 25 October 2010 Woods, Ben (2013-08-13)...
public domain in 2024. Sound recordings that were published in 1923 enter the public domain. The most famous work to enter the public domain in the United...
Domain adaptation is a field associated with machine learning and transfer learning. This scenario arises when we aim at learning a model from a source...
Malbolge (/mælˈboʊldʒ/) is a public domain esoteric programming language invented by Ben Olmstead in 1998, named after the eighth circle of hell in Dante's...
Binary Domain is a third-person shooter video game developed by Ryu Ga Gotoku Studio and published by Sega. It was released for PlayStation 3 and Xbox...
eschatology Mashiach ben Yoseph or Messiah ben Joseph (Hebrew: מָשִׁיחַ בֶּן־יוֹסֵף Māšīaḥ ben Yōsēf), also known as Mashiach bar/ben Ephraim (Aram./Heb...
copyright expires, it enters the public domain. The following is a list of creators whose works enter the public domain in 2024. Since laws vary globally,...
Rome. After Valerius Gratus deposed Ishmael ben Fabus from the high priesthood, he installed Eleazar ben Ananus, (15—16), a descendant of John Hyrcanus...
Ben Hecht and Charles MacArthur, it was first produced in 1928 and has been adapted for the cinema several times. The play entered the public domain in...
text from a publication now in the public domain: Schechter, Solomon; Bloch, Isaac (1901–1906). "Gershom ben Judah". In Singer, Isidore; et al. (eds.)...
Online Works by Franklin Works by Benjamin Franklin at LibriVox (public domain audiobooks) Works by Benjamin Franklin in eBook form at Standard Ebooks...
Network's Ben 10 franchise. Voiced by: Tara Strong – Ben 10 (4 and 10 years old), Ben 10: Ultimate Alien (10 years old in "Forge Of Creation"), Ben 10: Omniverse...
Satsuma Hōgen or 薩摩弁 Satsuma-ben), owing to both the prominence of the Satsuma Province and the region of the Satsuma Domain which spanned the former Japanese...
London: Wertheimer, Lea and Co. p. 50. Jewish Encyclopedia: “Angel, Ḥayyim Vidal Ben Shabbethai” by Gotthard Deutsch (1906). Now in public domain. v t e...
birth name, including patronymic, which was "Yosef ben Mattityahu", “Yoseph bar Mattityahu" or "Yosef ben Matityahu", literally meaning "Joseph son of Matthias"...
Global Information