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Vesiculo_matrix
crystal structure of vesicular stomatitis virus matrix protein
Identifiers
Symbol
Vesiculo_matrix
Pfam
PF06326
InterPro
IPR009397
SCOP2
1lg7 / SCOPe / SUPFAM
OPM superfamily
381
OPM protein
1lg7
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. The matrix (M) protein of the virus causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein.[1]
^Kopecky SA, Lyles DS (May 2003). "The cell-rounding activity of the vesicular stomatitis virus matrix protein is due to the induction of cell death". J. Virol. 77 (9): 5524–8. doi:10.1128/jvi.77.9.5524-5528.2003. PMC 153969. PMID 12692256.
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