The ventrolateral prefrontal cortex (VLPFC) is a section of the prefrontal cortex located on the inferior frontal gyrus, bounded superiorly by the inferior frontal sulcus and inferiorly by the lateral sulcus. It is attributed to the anatomical structures of Brodmann's area (BA) 47, 45 and 44 (considered the subregions of the VLPFC – the anterior, mid and posterior subregions).
Specific functional distinctions have been presented between the three Brodmann subregions of the VLPFC.[1][2][3] There are also specific functional differences in activity in the right and left VLPFC.[4] Neuroimaging studies employing various cognitive tasks have shown that the right VLPFC region is a critical substrate of control.[4] At present, two prominent theories feature the right VLPFC as a key functional region. From one perspective, the right VLPFC is thought to play a critical role in motor inhibition, where control is engaged to stop or override motor responses.[5] Alternatively, Corbetta and Shulman[2][6][7] have advanced the hypothesis that there are two distinct frontoparietal networks involved in spatial attention, with the right VLPFC being a component of a right-lateralized ventral attention network that governs reflexive reorienting. From this perspective, the right lateral PFC, along with a region spanning the right temporoparietal junction (TPJ) and the inferior parietal lobule, are engaged when abrupt onsets occur in the environment, suggesting that these regions are involved in re-orienting attention to perceptual events that occur outside the current focus of attention.[4] Also, the VLPFC is the end point of the ventral pathway (stream) that brings information about the stimuli's characteristics.[8]
^Gold, BT; Balota, DA; Jones, SJ; Powell, DK; Smith, CD; Andersen, AH (Jun 2006). "Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions". J Neurosci. 26 (24): 6523–6532. doi:10.1523/JNEUROSCI.0808-06.2006. PMC 6674026. PMID 16775140.
^ abBadre, D; Wagner, AD (Oct 2007). "Left ventrolateral prefrontal cortex and the cognitive control of memory". Neuropsychologia. 45 (13): 2883–901. doi:10.1016/j.neuropsychologia.2007.06.015. PMID 17675110.
^Danker, JF; Gunn, P; Anderson, JR (Nov 2008). "A rational account of memory predicts left prefrontal activation during controlled retrieval". Cereb Cortex. 18 (11): 2674–85. doi:10.1093/cercor/bhn027. PMC 2733322. PMID 18321871.
^ abcLevy, BJ; Wagner, AD (2004). "Cognitive control and right ventrolateral prefrontal cortex: reflexive reorienting, motor inhibition, and action updating". Ann N Y Acad Sci. 1224 (1): 40–62. doi:10.1111/j.1749-6632.2011.05958.x. PMC 3079823. PMID 21486295.
^Aron, AR (2004). "Review Inhibition and the right inferior frontal cortex". Trends Cogn Sci. 8 (4): 170–7. doi:10.1016/j.tics.2004.02.010. PMID 15050513.
^Corbetta, M; Shulman, GL (Mar 2002). "Control of goal-directed and stimulus-driven attention in the brain". Nat Rev Neurosci. 3 (3): 201–15. doi:10.1038/nrn755. PMID 11994752.
^Corbetta, M; Patel, G; Shulman, GL (May 2008). "The reorienting system of the human brain: from environment to theory of mind". Neuron. 58 (3): 306–24. doi:10.1016/j.neuron.2008.04.017. PMC 2441869. PMID 18466742.
^Lee, T. G.; Blumenfeld, R. S.; d'Esposito, M. (2013). "Disruption of Dorsolateral but Not Ventrolateral Prefrontal Cortex Improves Unconscious Perceptual Memories". Journal of Neuroscience. 33 (32): 13233–7. doi:10.1523/JNEUROSCI.5652-12.2013. PMC 3735892. PMID 23926275.
and 27 Related for: Ventrolateral prefrontal cortex information
brain anatomy, the prefrontalcortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. It is the association cortex in the frontal lobe...
The ventrolateralprefrontalcortex (VLPFC) is a section of the prefrontalcortex located on the inferior frontal gyrus, bounded superiorly by the inferior...
The ventromedial prefrontalcortex (vmPFC) is a part of the prefrontalcortex in the mammalian brain. The ventral medial prefrontal is located in the frontal...
often further divided into dorsolateral prefrontalcortex (BA8, BA9, BA10, BA46) and ventrolateralprefrontalcortex (BA45, BA47, BA44). The LPFC is primarily...
dorsolateral and ventrolateralprefrontalcortex. The dorsolateral prefrontalcortex is located on top of the ventrolateralprefrontalcortex and is mainly...
the ventrolateralprefrontalcortex, medial prefrontalcortex, dorsolateral prefrontalcortex and dorsomedial prefrontalcortex. The ventrolateral prefrontal...
strongly associated with certain social cognitive functions. The ventrolateralprefrontalcortex (VLPFC) is associated with emotional and inhibitory processing...
memory. This type of processing is directed, in part, by the ventrolateralprefrontalcortex (VLPFC). Pars triangularis is found in this region. When reading...
the ventrolateralprefrontalcortex and superior temporal sulcus brain regions, in the case of procedural justice, and the anterior cingulate cortex, anterior...
species, such as complex language processing localized to the ventrolateralprefrontalcortex (Broca's area). In humans and other primates, social and emotional...
posterior ventrolateralprefrontalcortex, the left premotor cortex, and the left posterior parietal cortex. Within the ventrolateralprefrontalcortex, Broca's...
fibromyalgia. Glutamate/creatine ratios within the bilateral ventrolateralprefrontalcortex were found to be significantly higher in fibromyalgia patients...
prefrontalcortex (D'Esposito et al. 1999, Eldreth et al. 2006, Smith & Jonides 1999). Imaging studies show frontal activation only in ventrolateral prefrontal...
The orbitofrontal cortex (OFC) is a prefrontalcortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making...
dorsolateral prefrontalcortex in working memory. One view was that the dorsolateral areas are responsible for spatial working memory and the ventrolateral areas...
those of the ventromedial prefrontalcortex, ventrolateralprefrontalcortex, dorsolateral prefrontalcortex, orbitofrontal cortex, and amygdala. Less pronounced...
behavioral inhibition on the basis of color, but not motion, in ventrolateralprefrontalcortex of macaque monkey". The Journal of Neuroscience. 21 (13): 4801–8...
such as the right caudate nucleus of the basal ganglia, left ventrolateralprefrontalcortex (VLPFC), and superior temporal gyrus. Neuroplasticity is most...
significant increase in brain activity in the ventrolateralprefrontalcortex bilaterally, along with the auditory cortex and parietal lobes. There was also decreased...
PMC 2778291. PMID 10570492. Badre D, Wagner AD (October 2007). "Left ventrolateralprefrontalcortex and the cognitive control of memory". Neuropsychologia. 45...
affect labeling results in higher brain activity within the ventrolateralprefrontalcortex (vlPFC), and reduced activity in the amygdala when compared...
2005). "Neural representation of vocalizations in the primate ventrolateralprefrontalcortex". Journal of Neurophysiology. 93 (2): 734–47. doi:10.1152/jn...
linked to dysfunction in the dorsolateral and ventrolateralprefrontalcortex, anterior cingulate cortex, striatum, and amygdala. A polymorphism in the...
also simulate previous experiences. In several studies, the ventrolateralprefrontalcortex, which supports language, was consistently active during emotion...