USP2 information

USP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HD5, 2IBI, 3NHE, 3V6C, 3V6E
Identifiers
Aliases	USP2, UBP41, USP9, ubiquitin specific peptidase 2
External IDs	OMIM: 604725 MGI: 1858178 HomoloGene: 3098 GeneCards: USP2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,381,711 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,095,627 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; sperm; ; secondary oocyte; ; left ventricle; ; anterior pituitary; ; gastric mucosa; ; caudate nucleus; ; kidney; ; nucleus accumbens; ; biceps brachii;
	Top expressed in
	seminiferous tubule; ; plantaris muscle; ; extensor digitorum longus muscle; ; skeletal muscle tissue; ; gastrocnemius muscle; ; ankle; ; soleus muscle; ; extraocular muscle; ; tibialis anterior muscle; ; quadriceps femoris muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; metal ion binding; peptidase activity; protein binding; identical protein binding; cysteine-type endopeptidase activity; hydrolase activity; ubiquitin protein ligase binding; cyclin binding; thiol-dependent deubiquitinase;
Cellular component	cytoplasm; centrosome; cell cortex; perinuclear region of cytoplasm; nucleus; nucleoplasm; membrane;
Biological process	ubiquitin-dependent protein catabolic process; rhythmic process; muscle organ development; protein stabilization; positive regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; circadian regulation of gene expression; proteolysis; circadian behavior; cell cycle; entrainment of circadian clock by photoperiod; locomotor rhythm; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	9099
	53376
	ENSG00000036672
	ENSMUSG00000032010
	O75604
	O88623
	NM_001243759; NM_004205; NM_171997
	NM_016808; NM_198091; NM_198092
	NP_001230688; NP_004196; NP_741994
NP_058088; NP_932759; NP_932760; NP_001394747; NP_001394748;
	NP_001394749; NP_001394750; NP_001394751; NP_001394752; NP_001394753; NP_001394754; NP_001394755; NP_001394756
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.^[5]^[6]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000036672 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032010 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ ^a ^b "Entrez Gene: USP2 ubiquitin specific peptidase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000036672 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032010 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP2 ubiquitin specific peptidase 2".

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Ubiquitin B

Deubiquitinating enzyme

Ubiquitin C

40S ribosomal protein S27a

Ashraf Brik

NEDD4L