proteasome-mediated ubiquitin-dependent protein catabolic process
protein folding
negative regulation of G2/M transition of mitotic cell cycle
protein ubiquitination
protein deubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
entry of bacterium into host cell
transmembrane transport
regulation of necroptotic process
membrane organization
endoplasmic reticulum mannose trimming
cellular iron ion homeostasis
regulation of hematopoietic stem cell differentiation
protein targeting to peroxisome
cytokine-mediated signaling pathway
modification-dependent protein catabolic process
interleukin-1-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6233
78294
Ensembl
ENSG00000143947
ENSMUSG00000020460
UniProt
P62979
P62983
RefSeq (mRNA)
NM_002954 NM_001135592 NM_001177413
NM_001033865 NM_024277
RefSeq (protein)
NP_001129064 NP_001170884 NP_002945
NP_001029037 NP_077239
Location (UCSC)
Chr 2: 55.23 – 55.24 Mb
Chr 11: 29.5 – 29.5 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.[5][6]
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000143947 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020460 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ab"Entrez Gene: RPS27A ribosomal protein S27a".
and 3 Related for: 40S ribosomal protein S27a information
40SribosomalproteinS27a is a protein that in humans is encoded by the RPS27A gene. Ubiquitin, a highly conserved protein that has a major role in targeting...
40Sribosomalprotein S30 is a protein that in humans is encoded by the FAU gene. This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly...
A ribosomalprotein (r-protein or rProtein) is any of the proteins that, in conjunction with rRNA, make up the ribosomal subunits involved in the cellular...