UGCG information

UGCG
Identifiers
Aliases	UGCG, GCS, GLCT1, UDP-glucose ceramide glucosyltransferase
External IDs	OMIM: 602874; MGI: 1332243; HomoloGene: 37763; GeneCards: UGCG; OMA:UGCG - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	111,935,369 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	59,222,833 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; jejunal mucosa; ; vena cava; ; trabecular bone; ; pericardium; ; bone marrow; ; oral cavity; ; lactiferous duct; ; human penis; ; nipple;
	Top expressed in
	morula; ; esophagus; ; lymph node; ; jejunum; ; ileum; ; secondary oocyte; ; visual cortex; ; blood; ; spleen; ; cingulate gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; ceramide glucosyltransferase activity; dihydroceramide glucosyltransferase activity; protein binding;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosphingolipid biosynthetic process; glycosphingolipid metabolic process; glucosylceramide biosynthetic process; epidermis development; lipid metabolism; sphingolipid metabolic process; cell differentiation; neuron development; establishment of skin barrier; intestinal lipid absorption; protein lipidation; regulation of signal transduction; keratinocyte differentiation; leptin-mediated signaling pathway; cornified envelope assembly;
	Sources:Amigo / QuickGO
Orthologs
	7357
	22234
	ENSG00000148154
	ENSMUSG00000028381
	Q16739
	O88693
	NM_003358
	NM_011673
	NP_003349; NP_003349.1
	NP_035803
	Wikidata
View/Edit Human	View/Edit Mouse

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.^[5]^[6]^[7]

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148154 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028381 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.
^ Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–234. doi:10.1159/000134731. PMID 9605861.
^ ^a ^b "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148154 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028381 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8643456-5] Ichikawa S, Sakiyama H, Suzuki G, Hidari KI, Hirabayashi Y (Jul 1996). "Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis". Proc Natl Acad Sci U S A. 93 (10): 4638–4643. Bibcode:1996PNAS...93.4638I. doi:10.1073/pnas.93.10.4638. PMC 39331. PMID 8643456.

[pmid9605861-6] Ichikawa S, Ozawa K, Hirabayashi Y (Jun 1998). "Assignment of a UDP-glucose:ceramide glucosyltransferase gene (UGCG) to human chromosome band 9q31 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 233–234. doi:10.1159/000134731. PMID 9605861.

[entrez-7] "Entrez Gene: UGCG UDP-glucose ceramide glucosyltransferase".

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