This article is about the antigen. For information about the tuberculin skin test, see Mantoux test.
Tuberculin
Clinical data
Trade names
Aplisol, Mantoux, PPD, others
AHFS/Drugs.com
Monograph
Routes of administration
intradermal
ATC code
V04CF01 (WHO)
Legal status
Legal status
US: ℞-only
Identifiers
ChemSpider
none
Tuberculin, also known as purified protein derivative, is a combination of proteins that are used in the diagnosis of tuberculosis.[1] This use is referred to as the tuberculin skin test and is recommended only for those at high risk.[2] Reliable administration of the skin test requires large amounts of training, supervision, and practice. Injection is done into the skin.[2] After 48 to 72 hours, if there is more than a five to ten millimeter area of swelling, the test is considered positive.[2]
Common side effects include redness, itchiness, and pain at the site of injection.[1] Allergic reactions may occasionally occur.[1] The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of mycobacteria.[2] The test may be falsely negative within ten weeks of infection, in those less than six months old, and in those who have been infected for many years.[2] Use is safe in pregnancy.[2]
Tuberculin was discovered in 1890 by Robert Koch.[3] Koch, best known for his work on the etiology of tuberculosis (TB), laid down various rigorous guidelines that aided the establishment between a pathogen and the specific disease that followed that were later named Koch's postulates.[4] Although he initially believed it would cure tuberculosis, this was later disproved.[3] Tuberculin is made from an extract of Mycobacterium tuberculosis.[1]
It is on the World Health Organization's List of Essential Medicines.[5]
^ abcd"Tuberculin". The American Society of Health-System Pharmacists. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
^ abcdef"Tuberculin Skin Testing". www.cdc.gov. Archived from the original on 9 January 2017. Retrieved 8 January 2017.
^ abComstock GW (2013). "Tuberculosis". In Evans AS (ed.). Bacterial Infections of Humans: Epidemiology and Control. Springer. p. 605. ISBN 9781475711400. Archived from the original on 2017-01-09.
^Tyagi JS (2006-09-01). "The timeless legacy of Robert Koch". Resonance. 11 (9): 20–28. doi:10.1007/BF02834330. ISSN 0973-712X. S2CID 82004821.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Tuberculin, also known as purified protein derivative, is a combination of proteins that are used in the diagnosis of tuberculosis. This use is referred...
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(booster) BCG vaccinations are given. In contrast, the specificity of tuberculin skin test (TST) varies depending on timing of BCG and whether repeated...
tuberculosis therapeutic agent tuberculin was under study; and Ehrlich had even injected himself with it. In the ensuing tuberculin scandal, Ehrlich tried to...
financially unsustainable after manufacturers could not be found for tuberculin or Heaf guns. Until 2005, the test was used in the United Kingdom to determine...
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active tuberculosis. Persons with these findings, if they have a positive tuberculin skin test reaction, should be considered high-priority candidates for...
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lymphocytes. It was also shown to be produced in human lymphocytes. or tuberculin-sensitized mouse peritoneal lymphocytes challenged with Mantoux test (PPD);...
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[citation needed] A pre-injection tuberculin skin test is usually carried out before administering BCG. A reactive tuberculin skin test is a contraindication...
as "Koch's postulates". Although his proposed tuberculosis treatment, tuberculin, seemingly failed, it soon was used to test for infection with the involved...
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