HTLV-I-associated myelopathy (HAM) or HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)[1]
HTLV-1 which causes TSP
Specialty
Neurology
Symptoms
Bowel dysfunction[2]
Causes
HTLV-1 retrovirus causes 80% of cases[3]
Diagnostic method
Lumbar puncture, MRI[2]
Treatment
Interferon alpha, corticosteroids[3]
Tropical spastic paraparesis (TSP), is a medical condition that causes weakness, muscle spasms, and sensory disturbance by human T-lymphotropic virus resulting in paraparesis, weakness of the legs. As the name suggests, it is most common in tropical regions, including the Caribbean.[4] Blood transfusion products are screened for human T-lymphotropic virus 1 (HTLV-1) antibodies, as a preventive measure.[5]
^Oh, Unsong; Jacobson, Steven (23 December 2016). "Treatment of HTLV-I-Associated Myelopathy / Tropical Spastic Paraparesis: Towards Rational Targeted Therapy". Neurol Clin. 26 (3): 781–x. doi:10.1016/j.ncl.2008.03.008. PMC 2610848. PMID 18657726.
^ abCite error: The named reference pat was invoked but never defined (see the help page).
^ ab"Tropical Spastic Paraparesis Information Page | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved 3 January 2018.
^"Tropical Spastic Paraparesis Information Page: National Institute of Neurological Disorders and Stroke (NINDS)". www.ninds.nih.gov. Archived from the original on 2016-12-15. Retrieved 2015-08-13.
^Centers for Disease Control (CDC) (1988). "Licensure of screening tests for antibody to human T-lymphotropic virus type I". MMWR. 37 (48): 736–40, 745–7. PMID 3143058.
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