Investigation performed during pregnancy in the 2nd trimester to check chromosomal abnormalities
Not to be confused with Triple test score, a diagnostic tool for examining potentially cancerous breasts.
Triple test
Synonyms
Triple screen,Bart's test
Test of
chromosomal abnormalities
The triple test, also called triple screen, the Kettering test or the Bart's test, is an investigation performed during pregnancy in the second trimester to classify a patient as either high-risk or low-risk for chromosomal abnormalities (and neural tube defects).
The term "multiple-marker screening test" is sometimes used instead.[1][2] This term can encompass the "double test" and "quadruple test" (described below).
The Triple screen measures serum levels of AFP, estriol, and beta-hCG, with a 70% sensitivity and 5% false-positive rate. It is complemented in some regions of the United States, as the Quad screen (adding inhibin A to the panel, resulting in an 81% sensitivity and 5% false-positive rate for detecting Down syndrome when taken at 15–18 weeks of gestational age)[3] and other prenatal diagnosis techniques, although it remains widely used in Canada[4] and other countries. A positive screen indicates an increased risk of chromosomal abnormalities (and neural tube defects), and such patients are then referred for more sensitive and specific procedures to receive a definitive diagnosis, often prenatal diagnosis via amniocentesis, although the stronger screening option of cell-free fetal DNA screening (also popularly known as noninvasive prenatal screening) is frequently offered. The Triple test can be understood as an early predecessor to a long line of subsequent technological improvements. In some American states, such as Missouri, Medicaid reimburses only for the Triple test and not other potentially more accurate screening tests, whereas California offers Quad tests to all pregnant women.[5]
While the triple test can be performed at any point between 15 and 21.9 weeks of gestation, the highest detection rate for open neural defects is given by a test performed between 16 and 18 weeks of gestation.[6]
^Renier MA, Vereecken A, Van Herck E, Straetmans D, Ramaekers P, Buytaert P (March 1998). "Second trimester maternal dimeric inhibin-A in the multiple-marker screening test for Down's syndrome". Hum. Reprod. 13 (3): 744–8. doi:10.1093/humrep/13.3.744. PMID 9572446.
^Yudin MH, Prosen TL, Landers DV (October 2003). "Multiple-marker screening in human immunodeficiency virus-positive pregnant women: Screen positivity rates with the triple and quad screens". Am. J. Obstet. Gynecol. 189 (4): 973–6. doi:10.1067/S0002-9378(03)01053-6. PMID 14586337.
^Lao M, Calhoun BC, Bracero LA, Wang Y, Seybold DJ, Broce M, Hatjis CG (2009). "The ability of the quadruple test to predict adverse perinatal outcomes in a high-risk obstetric population". J Med Screen. 16 (2): 55–59. doi:10.1258/jms.2009.009017. PMID 19564516. S2CID 23214929.
^sogc.org Archived 2009-06-28 at the Wayback Machine
^cdph.ca.gov Archived 2017-02-12 at the Wayback Machine
^"Understanding the Triple Test". Sonora Quest Laboratories. Retrieved 1 February 2023.
The tripletest, also called triple screen, the Kettering test or the Bart's test, is an investigation performed during pregnancy in the second trimester...
The tripletest score is a diagnostic tool for examining potentially cancerous breasts. Diagnostic accuracy of the tripletest score is nearly 100%. Scoring...
triple century (an individual score of 300 runs or more) in Test cricket has been scored on 31 occasions by 27 batsmen from eight of the twelve Test-cricket...
The Triple Sugar Iron (TSI) test is a microbiological test roughly named for its ability to test a microorganism's ability to ferment sugars and to produce...
or triple bolus test or a dynamic pituitary function test is a medical diagnostic procedure used to assess a patient's pituitary function. A triple bolus...
mandated that the elections to state municipalities should follow the tripletest condition. On 27 November 2023, PIL was filed before Patna High Court...
The Triple Nine Society (TNS) is an international high-IQ society for adults whose score on a standardized test demonstrates an IQ at or above the 99...
estriol, and h-hCG (hyperglycosolated hCG) in the woman's serum. The tripletest measures serum levels of AFP, estriol, and beta-hCG, with a 70% sensitivity...
was reinstated. However, the Fastest Finger First was removed and a TripleTest was introduced in which contestants took three general knowledge questions...
Look up TTT in Wiktionary, the free dictionary. TTT or Triple T may stand for: TTT (education), a life skills education program in India TT Technologies...
nicknamed The Test of the Champion, The Test of Champions and The Run for the Carnations, is the traditional third and final leg of the Triple Crown. It is...
The triple jump, sometimes referred to as the hop, step and jump or the hop, skip and jump, is a track and field event, similar to long jump. As a group...
Company's Flight Test Facility at Edwards AFB, serving there until 1998. In 1990, he cowrote the book To Fly & Fight—Memoirs of a Triple Ace. On July 19...
Paul Michael Levesque (born July 27, 1969), better known by the ring name Triple H, is an American business executive, actor, and retired professional wrestler...
American racehorse trainer who trained the 2015 Triple Crown winner American Pharoah and 2018 Triple Crown winner Justify. Baffert's horses have won a...
batter to score a triple century in Test cricket. He made his India debut in the 2016 away ODI against Zimbabwe. He made his Test debut against England...
Bluegill Triple Prime test, although one report by the U.S. federal government reported the test yield as 200 kilotons. As with the other Fishbowl tests, a...
pregnancy.[citation needed] hCG levels are also a component of the tripletest, a screening test for certain fetal chromosomal abnormalities/birth defects. High...
A Pythagorean triple consists of three positive integers a, b, and c, such that a2 + b2 = c2. Such a triple is commonly written (a, b, c), a well-known...
intelligence quotient (IQ) is a total score derived from a set of standardised tests or subtests designed to assess human intelligence. The abbreviation "IQ"...
the motorcycle press, with one magazine capturing a road test of the completed Street Triple. Later articles reported on leaked design shots of the new...
armoured targets defined by NATO designed to test the armour penetration of weapons. The purpose of the triple heavy target is to represent the difficulty...
made by an Indian in Test cricket (319 against South Africa at M. A. Chidambaram Stadium in Chennai), which was also the fastest triple century in the history...
organic chemistry, the bromine test is a qualitative test for the presence of unsaturation (carbon-to-carbon double or triple bonds), phenols and anilines...