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Trimethylamine dehydrogenase information


trimethylamine dehydrogenase
Identifiers
EC no.1.5.8.2
CAS no.39307-09-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a trimethylamine dehydrogenase (EC 1.5.8.2) is an enzyme that catalyzes the chemical reaction

trimethylamine + H2O + electron-transferring flavoprotein dimethylamine + formaldehyde + reduced electron-transferring flavoprotein

The 3 substrates of this enzyme are trimethylamine, H2O, and electron-transferring flavoprotein, whereas its 3 products are dimethylamine, formaldehyde, and reduced electron-transferring flavoprotein.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating). This enzyme participates in methane metabolism.

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Trimethylamine dehydrogenase

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In enzymology, a trimethylamine dehydrogenase (EC 1.5.8.2) is an enzyme that catalyzes the chemical reaction trimethylamine + H2O + electron-transferring...

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TIM barrel

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the C-terminal end of the TIM-barrel. Trimethylamine dehydrogenase catalyzes the conversion of trimethylamine to formaldehyde. This reaction requires...

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Dimethylamine dehydrogenase

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structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition"....

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Electron transport chain

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different energy sources: formate dehydrogenase, lactate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, H2 dehydrogenase (hydrogenase), electron transport...

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Phenethylamine

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the small intestine by monoamine oxidase B (MAO-B) and then aldehyde dehydrogenase (ALDH), which converts it to phenylacetic acid. This means that for...

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Methylotroph

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Methanol is then oxidized to formaldehyde through the action of methanol dehydrogenase (MDH) in bacteria, or a non-specific alcohol oxidase in yeast. Electrons...

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Intestinal metabolic bromhidrosis syndrome

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(ammonia) Rotten eggs like body odor (sulfides) Rotten fish like body odor (trimethylamine) Rotten meat like body odor (putrescine) Cabbage like body odor (methanethiol)...

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ETFB

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"Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein". The Journal of Biological...

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Choline

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often encountered as a colorless viscous hydrated syrup that smells of trimethylamine (TMA). Aqueous solutions of choline are stable, but the compound slowly...

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Oxidative phosphorylation

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molecular models at Universidade Fernando Pessoa: NADH dehydrogenase succinate dehydrogenase Coenzyme Q - cytochrome c reductase cytochrome c oxidase...

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ETFA

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"Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein". The Journal of Biological...

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Campylobacter jejuni

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use nitrate, nitrite, sulfur oxides (such as dimethyl sulfoxide or trimethylamine N-oxide), or fumarate as terminal electron acceptors as well to survive...

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Fluoxymesterone

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material (1.16) is sulfonylated by p-toluenesulfonyl chloride; addition of trimethylamine (base) deprotonates the 11α-carbon, yielding an (E2) elimination of...

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Salisediminibacterium

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anaerobic respiratory growth with Se(IV), As(V), nitrate, nitrite, trimethylamine oxide and fumarate as electron acceptors. Analyses of genome sequences...

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Escherichia coli

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substrates such as oxygen, nitrate, fumarate, dimethyl sulfoxide, and trimethylamine N-oxide. E. coli is classified as a facultative anaerobe. It uses oxygen...

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Radical SAM

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CofH - FO synthase, CofH subunit (cofactor biosynthesis - F420) CutD - trimethylamine lyase-activating enzyme DarE - darobactin maturase DesII - D-desosamine...

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Metal carbonyl

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ligand is often susceptible to attack by nucleophiles. For example, trimethylamine oxide and potassium bis(trimethylsilyl)amide convert CO ligands to CO2...

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Sabyasachi Sarkar

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April 2013). "Replica of a Fishy Enzyme: Structure–Function Analogue of Trimethylamine-N-Oxide Reductase". Inorganic Chemistry. 52 (9): 5316–5327. doi:10.1021/ic4002576...

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