soluble in acetonitrile, dichloromethane, diethyl ether, sulfolane
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Trifluoroperacetic acid (trifluoroperoxyacetic acid, TFPAA) is an organofluorine compound, the peroxy acid analog of trifluoroacetic acid, with the condensed structural formula CF 3COOOH.[Note 1] It is a strong oxidizing agent for organic oxidation reactions, such as in Baeyer–Villiger oxidations of ketones.[1] It is the most reactive of the organic peroxy acids, allowing it to successfully oxidise relatively unreactive alkenes to epoxides where other peroxy acids are ineffective.[2] It can also oxidise the chalcogens in some functional groups, such as by transforming selenoethers to selones.[3] It is a potentially explosive material[4] and is not commercially available, but it can be quickly prepared as needed.[5] Its use as a laboratory reagent was pioneered and developed by William D. Emmons.[6][7]
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and 12 Related for: Trifluoroperacetic acid information
Trifluoroperaceticacid (trifluoroperoxyacetic acid, TFPAA) is an organofluorine compound, the peroxy acid analog of trifluoroacetic acid, with the condensed...
carbonate but can leach the H2O2 out of it. A method for generating trifluoroperaceticacid in situ for use in Baeyer–Villiger oxidations from sodium percarbonate...
other fluorinated compounds such as trifluoroacetic anhydride, trifluoroperaceticacid, and 2,2,2-trifluoroethanol. It is a reagent used in organic synthesis...
each includes a step in which a dioxolane system is formed using trifluoroperaceticacid (TFPAA), prepared by the hydrogen peroxide – urea method. This...
subsequent NIH shift rearrangement. Oxidation of thiophene by trifluoroperaceticacid also demonstrates both reaction pathways. The major pathway forms...
in cases where the sulfenyl chloride, RSCl, results instead, a trifluoroperaceticacid oxidation affords the desired product, as in the case of 2,2,2-trifluoro-1...
diisobutylaluminum hydride, and finally a Prilezhaev epoxidation with trifluoroperaceticacid affords scopine. Aposcopolamine Umbelliferone Werner, Gottfried;...
instead, as happens with 2,2,2-trifluoro-1,1-diphenylethanethiol. A trifluoroperaceticacid oxidation then provides a general approach to formation of sulfinyl...
probably due to π-stacking of the aromatic systems. Oxidation with trifluoroperaceticacid or hydrogen peroxide gives 2,3,4,5,6,6-hexamethyl-2,4-cyclohexadienone:)...
diisobutylaluminum hydride (DIBAL-H) followed by epoxidation with trifluoroperaceticacid affords the target. (13) Rigby, J.; Pigge, C. Org. React. 1997...
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