Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound.[1][2][3][4] Trifluoromethylated compounds are of some importance in pharmaceutical industry and agrochemicals. Several notable pharmaceutical compounds have a trifluoromethyl group incorporated: fluoxetine, mefloquine, Leflunomide, nulitamide, dutasteride, bicalutamide, aprepitant, celecoxib, fipronil, fluazinam, penthiopyrad, picoxystrobin, fluridone, norflurazon, sorafenib and triflurazin. A relevant agrochemical is trifluralin. The development of synthetic methods for adding trifluoromethyl groups to chemical compounds is actively pursued in academic research.
^Tomashenko, O. A.; Grushin, V. V. (2011). "Aromatic Trifluoromethylation with Metal Complexes". Chemical Reviews. 111 (8): 4475–4521. doi:10.1021/cr1004293. PMID 21456523.
^Furuya, T.; Kamlet, A. S.; Ritter, T. (2011). "Catalysis for fluorination and trifluoromethylation". Nature. 473 (7348): 470–477. Bibcode:2011Natur.473..470F. doi:10.1038/nature10108. PMC 3119199. PMID 21614074.
^Besset, T.; Schneider, C. D.; Cahard, D. (2012). "Tamed Arene and Heteroarene Trifluoromethylation". Angewandte Chemie International Edition. 51 (21): 5048–5050. doi:10.1002/anie.201201012. PMID 22488902.
^Alonso, C. N.; Martínez De Marigorta, E.; Rubiales, G.; Palacios, F. (2015). "Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes". Chemical Reviews. 115 (4): 1847–1935. doi:10.1021/cr500368h. PMID 25635524.
and 18 Related for: Trifluoromethylation information
Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound. Trifluoromethylated...
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Russell, Jamie; Roques, Nicolas (1998-11-05). "Effective nucleophilic trifluoromethylation with fluoroform and common base". Tetrahedron. 54 (45): 13771–13782...
wide range of functional groups. Its complexes also catalyze the trifluoromethylation of aryl chlorides and aminations of aryl halides. BrettPhos has been...
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electronic equipment fires. It is used in the rhodium-catalyzed α-trifluoromethylation of α,β-unsaturated ketones. It can be used as a new generation fire...
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an intern at Merck Research Laboratories, where she investigated trifluoromethylation using metal catalysts. In 2008 Kalow joined Princeton University...
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