Trichodysplasia spinulosa polyomavirus information
Member virus of Human polyomavirus 8
Trichodysplasia spinulosa-associated polyomavirus
Virus classification
(unranked):
Virus
Realm:
Monodnaviria
Kingdom:
Shotokuvirae
Phylum:
Cossaviricota
Class:
Papovaviricetes
Order:
Sepolyvirales
Family:
Polyomaviridae
Genus:
Alphapolyomavirus
Species:
Human polyomavirus 8
Virus:
Trichodysplasia spinulosa-associated polyomavirus
Synonyms
Trichodysplasia spinulosa polyomavirus
Trichodysplasia spinulosa polyomavirus (also known as Trichodysplasia spinulosa-associated polyomavirus, abbreviated TSPyV or TSV) is a member virus of Human polyomavirus 8[1] that infects human hosts. First discovered in 2010, TSPyV is associated with Trichodysplasia spinulosa, a rare skin disease only seen in immunocompromised patients.[2] The virus causes hyperproliferation and enlargement of hair follicles by modulating PP2A protein phosphatase signaling pathways.[3] TSPyV was the eighth human polyomavirus to be discovered, and one of four associated with human disease, out of 13 human polyomaviruses known as of the 2015 update to polyomavirus taxonomy released by the International Committee on Taxonomy of Viruses.[4][5][6]
^"Genus: Alphapolyomavirus" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 17 June 2019.[dead link]
^Van der Meijden, E; Janssens, RWA; Lauber, C; Bouwes Bavinck, JN; Gorbalenya, AE; et al. (2010). "Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient". PLOS Pathog. 6 (7): e1001024. doi:10.1371/journal.ppat.1001024. PMC 2912394. PMID 20686659.
^Nguyen, HP; Patel, A; Simonette, RA; Rady, PL; Tyring, SK; et al. (2014). "Binding of the Trichodysplasia Spinulosa–Associated Polyomavirus Small T Antigen to Protein Phosphatase 2A: Elucidation of a Potential Pathogenic Mechanism in a Rare Skin Disease". JAMA Dermatology. 150 (11): 1234–1236. doi:10.1001/jamadermatol.2014.1095. PMID 25389794. S2CID 42096048.
^ICTV. "Virus Taxonomy: 2015 Release". Retrieved 26 July 2016.
^Polyomaviridae Study Group of the International Committee on Taxonomy of, Viruses; Calvignac-Spencer, S; Feltkamp, MC; Daugherty, MD; Moens, U; Ramqvist, T; Johne, R; Ehlers, B (29 February 2016). "A taxonomy update for the family Polyomaviridae". Archives of Virology. 161 (6): 1739–50. doi:10.1007/s00705-016-2794-y. hdl:10037/13151. PMID 26923930.
^DeCaprio, JA; Garcea, RL (2013). "A cornucopia of human polyomaviruses". Nat. Rev. Microbiol. 11 (4): 264–76. doi:10.1038/nrmicro2992. PMC 3928796. PMID 23474680.
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