RNA phosphodiester bond hydrolysis, endonucleolytic
production of siRNA involved in RNA interference
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7247
22099
Ensembl
ENSG00000211460
ENSMUSG00000026374
UniProt
Q15631
Q62348
RefSeq (mRNA)
NM_001261401 NM_004622
NM_011650
RefSeq (protein)
NP_001248330 NP_004613
NP_035780
Location (UCSC)
Chr 2: 121.74 – 121.77 Mb
Chr 1: 118.22 – 118.24 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Translin is a DNA-binding protein that in humans is encoded by the TSN gene.[5][6][7] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[8][9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000211460 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026374 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (July 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
^Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
^"Entrez Gene: TSN translin".
^Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (August 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. Bibcode:2009Sci...325..750L. doi:10.1126/science.1176325. PMC 2855623. PMID 19661431.
^Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (June 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC 3109212. PMID 21552258.
^Ha M, Kim VN (August 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.
Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component...
Look up TSN in Wiktionary, the free dictionary. TSN may refer to: Translin, a DNA binding protein involved in microRNA function Taxonomic serial number...
researchers. 24 March Scientists at Florida Atlantic University identify translin as a gene responsible for sleep deprivation and metabolic disorders. The...
et al. (2003). "Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and...
PMID 11564868. Hasegawa T, Isobe K (1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochim. Biophys. Acta. 1428 (2–3): 161–8...
"DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX)". Journal of Cell Science. 115 (Pt 1): 207–16...
characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002...
thought to regulate TRAX/Translin complex formation. Protein C1D may have a protective effect against relation to the TRAX/Translin complex formation of DNA...
characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002...
M (January 1997). "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters. 401 (2–3): 109–12. doi:10.1016/S0014-5793(96)01444-5...
characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X". Genomics. 79 (6): 799–808. doi:10.1006/geno.2002...