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Tn antigen refers to the monosaccharide structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, considered as an antigen.[1] The initials stand for Thomsen-nouveau. Tn antigen is expressed in most carcinomas.[2]
Addition of an additional galactose monosaccharide creates a disaccharide antigen: the Thomsen-Friedenreich antigen (Gal(b1-3)GalNAc). The sialyl Tn antigen (STn antigen) is formed by elongation with sialic acid (Neu5Ac(a2-6)GalNAc) rather than galactose.
^I. Brockhausen, H. Schachter, P. Stanley, Essentials of Glycobiology, 2nd edition. A. Varki, R. Cummings, J. Esko, Eds, Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 9, O-GalNAc Glycans
^Zhou, Qun (6 December 2016). Recent Progress in Glycotherapy. Bentham Science Publishers. p. 8. ISBN 978-1-68108-391-9.
Tnantigen refers to the monosaccharide structure N-acetylgalactosamine (GalNAc) linked to serine or threonine by a glycosidic bond, considered as an antigen...
In immunology, an antigen (Ag) is a molecule, moiety, foreign particulate matter, or an allergen, such as pollen, that can bind to a specific antibody...
M blood group antigen. A lectin from coconut milk is used to identify Theros antigen. A lectin from Carex is used to identify R antigen. In neuroscience...
beta-3-galactosyltransferase (C1GALT1). C1GALT1 is associated with the T-Tnantigen system. There is some evidence that mutations in the C1GALT1 gene may...
is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes. For human blood transfusions, it is the most important...
specific antigens. Antigen literally means "antibody generator", as it is the presence of an antigen that drives the formation of an antigen-specific...
(GalNAc) on a peptide/proteins (also called Tnantigen) with an α2-6 linkage to produce the sialyl-Tnantigen. It has been shown that the enzyme prefers...
Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is...
trial number NCT02215967 for "Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma" at ClinicalTrials.gov "Celgene...
where it can also be sialylated. These tumor-associated antigens (Neu5Acα2,6-Tn, and NeuGcα2,6-Tn) are also bound. CLEC10A has also been shown to bind GalNAc...
B. Liebe, H. Kunz: Festphasensynthese eines tumorassoziierten Sialyl-Tn-Antigen-Glycopeptids mit einer Partialsequenz aus dem "Tandem Repeat" des MUC-1-Mucins...
function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface for...
bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host. Antigens are any substances that elicit...
immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I...
Initial studies found that Siglec-6 binds to sialyl-Tnantigen (Neu5Acα2–6GalNAcα) but not to Tnantigen (GalNAcα), 6′-sialyl-lactose (Neu5Acα2–6Galβ1–4Glc)...
absence of antibodies and inherited antigenic substances on the surface of red blood cells (RBCs). These antigens may be proteins, carbohydrates, glycoproteins...
through self-renewal. TSCM represent an intermediate subset between naïve (Tn) and central memory (Tcm) T cells, expressing both naïve T cells markers,...
antigens, molecules on their surface that can bind to antibody proteins or T-cell receptors, triggering an immune system response. The tumor antigens...
sialyl Lewis(a), and sialyl Tnantigens in colorectal cancer patients: multivariate analysis of predictive factors for serum antigen levels". Journal of Gastroenterology...
by heat or chemical treatment to produce a toxoid. These retain their antigenic specificity and can be used to produce antitoxins and, in the case of...
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