Thymineless death is the phenomenon by which bacteria, yeasts and mammalian cells undergo cell death when they are starved of thymidine triphosphate (dTTP), an essential precursor for DNA replication.[1] This phenomenon underlies the mechanism of action of several antibacterial, antimalarial and anticancer agents, such as trimethoprim, sulfamethoxazole, methotrexate and fluorouracil.[1][2][3]
^ abAhmad, S. I.; Kirk, S. H.; Eisenstark, A. (October 1998). "Thymine Metabolism and Thymineless Death in Prokaryotes and Eukaryotes". Annual Review of Microbiology. 52: 591–625. doi:10.1146/annurev.micro.52.1.591. PMID 9891809.
^Longley, D. B.; Harkin, D. P.; Johnston, P. G. (2003). "5-Fluorouracil: Mechanisms of action and clinical strategies". Nature Reviews Cancer. 3 (5): 330–338. doi:10.1038/nrc1074. PMID 12724731. S2CID 4357553.
^Friedman, M. A.; Sadée, W. (1978). "The fluoropyrimidines: Biochemical mechanisms and design of clinical trials". Cancer Chemotherapy and Pharmacology. 1 (2): 77–82. doi:10.1007/bf00254040. PMID 373913. S2CID 10958670.
Thyminelessdeath is the phenomenon by which bacteria, yeasts and mammalian cells undergo cell death when they are starved of thymidine triphosphate (dTTP)...
proliferating (such as fast-growing death cancer tumors). By inhibiting this step, cells die from a thyminelessdeath because they have no thymine to create...
scarcity in dTMP, so rapidly dividing cancerous cells undergo cell death via thyminelessdeath. Calcium folinate provides an exogenous source of reduced folinates...
process cause various biological and genetic abnormalities, such as thyminelessdeath. The enzyme is an important target for certain chemotherapeutic drugs...
"Antifolate-Induced Depletion of Intracellular Glycine and Purines Inhibits ThyminelessDeath in E. Coli". ACS Chemical Biology. 5 (8): 787–795. doi:10.1021/cb100096f...
(December 1975). "Studies of intracellular thymidine nucleotides. Thyminelessdeath and the recovery after re-addition of thymine in Escherichia coli...
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