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Medical condition
Tangier disease
Other names
Familial alpha-lipoprotein deficiency[1]: 535
Specialty
Endocrinology
Tangier disease or hypoalphalipoproteinemia is an extremely rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein (HDL), often referred to as "good cholesterol", in the bloodstream.[2] Worldwide, approximately 100 cases have even been identified.[3][4]
The disorder was originally discovered on Tangier Island off the coast of Virginia, but has now been identified in people from many countries.
^James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
^Rust S, Rosier M, Funke H, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 1999; 22:352.
Tangierdisease or hypoalphalipoproteinemia is an extremely rare inherited disorder characterized by a severe reduction in the amount of high density...
content of cardiolipins is strongly increased. Tangierdisease is also linked to CL abnormalities. Tangierdisease is characterized by very low blood plasma...
discovered that a mutation in the ABCA1 protein is responsible for causing Tangierdisease by several groups in 1998. Gerd Schmitz's group in Germany and Michael...
atherosclerotic cardiovascular diseases (ASCVD), which include coronary artery disease, cerebrovascular disease, and peripheral artery disease. Although dyslipidemia...
It is therefore not surprising that splenomegaly is associated with any disease process that involves abnormal red blood cells being destroyed in the spleen...
the iodide. NIS activity helps in the diagnosis and treatment of thyroid disease, including the highly successful treatment of thyroid cancer with radioiodide...
type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the...
include Mendelian diseases and complex genetic disorders such as cystic fibrosis, adrenoleukodystrophy, Stargardt disease, Tangierdisease, immune deficiencies...
including Tangierdisease, and with systemic non-neuropathic amyloidosis. Apo-AI is often used as a biomarker for prediction of cardiovascular diseases. The...
"Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangierdisease". Biochemical and Biophysical Research Communications. 283 (4): 821–30...
involved in cholesterol homeostasis like ABCA1 which is defective in Tangierdisease. A common feature of many metabolic pathways is their control by retinoid...
native of Tangier, a seaport in Morocco, on the Strait of Gibraltar" and "a native of Tangier." The name was first used for fruit coming from Tangier, Morocco...
The Tangier Garrison was the land force which oversaw the defence of English Tangier between 1661 and 1684 when it was evacuated. It was part of the English...
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