Tafazzin is a protein that in humans is encoded by the TAFAZZIN gene.[5] Tafazzin is highly expressed in cardiac and skeletal muscle, and functions as a phospholipid-lysophospholipid transacylase (it belongs to phospholipid:diacylglycerol acyltransferases).[6][7] It catalyzes remodeling of immature cardiolipin to its mature composition containing a predominance of tetralinoleoyl moieties.[8] Several different isoforms of the tafazzin protein are produced from the TAFAZZIN gene. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. Most isoforms are found in all tissues, but some are found only in certain types of cells.[9][5] Mutations in the TAFAZZIN gene have been associated with mitochondrial deficiency, Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, left ventricular noncompaction (LVNC), breast cancer, papillary thyroid carcinoma, non-small cell lung cancer, glioma, gastric cancer, thyroid neoplasms, and rectal cancer.[5][10][11][12]
It is important to note that the TAZ gene was frequently confused with a protein called TAZ (transcriptional coactivator with PDZ-binding motif, a 50 kDA protein). which is a part of the Hippo pathway and entirely unrelated to the gene of interest. The Hippo pathway TAZ protein has an official gene symbol of WWTR1.
^ abcGRCh38: Ensembl release 89: ENSG00000102125 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009995 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abc"TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase [ Homo sapiens (human) ]". This article incorporates text from this source, which is in the public domain.
^Xu Y, Zhang S, Malhotra A, Edelman-Novemsky I, Ma J, Kruppa A, et al. (October 2009). "Characterization of tafazzin splice variants from humans and fruit flies". The Journal of Biological Chemistry. 284 (42): 29230–9. doi:10.1074/jbc.M109.016642. PMC 2781466. PMID 19700766.
^Xu Y, Malhotra A, Ren M, Schlame M (December 2006). "The enzymatic function of tafazzin". The Journal of Biological Chemistry. 281 (51): 39217–24. doi:10.1074/jbc.M606100200. PMID 17082194.
^Acehan D, Vaz F, Houtkooper RH, James J, Moore V, Tokunaga C, et al. (January 2011). "Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome". The Journal of Biological Chemistry. 286 (2): 899–908. doi:10.1074/jbc.M110.171439. PMC 3020775. PMID 21068380.
^"TAZ". Genetics Home Reference. NCBI. This article incorporates text from this source, which is in the public domain.
^Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, et al. (July 2012). "The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition". The Journal of Biological Chemistry. 287 (31): 26245–53. doi:10.1074/jbc.M112.382036. PMC 3406709. PMID 22692215.
^Ge L, Li DS, Chen F, Feng JD, Li B, Wang TJ (July 2017). "TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cells". International Journal of Oncology. 51 (1): 307–315. doi:10.3892/ijo.2017.3998. PMID 28534974.
^Chen M, Zhang Y, Zheng PS (2017). "Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis". PLOS ONE. 12 (5): e0177171. Bibcode:2017PLoSO..1277171C. doi:10.1371/journal.pone.0177171. PMC 5425199. PMID 28489874.
Tafazzin is a protein that in humans is encoded by the TAFAZZIN gene. Tafazzin is highly expressed in cardiac and skeletal muscle, and functions as a...
is the source of the name of the protein Tafazzin, due to the difficulties involved in identifying the tafazzin gene. "I rischi del tafazzismo". ilGiornale...
Burlington Township High School Bluetooth headset An alternate name for tafazzin This disambiguation page lists articles associated with the title BTHS...
has a mutation in the gene coding for tafazzin, an enzyme involved in the biosynthesis of cardiolipin. Tafazzin is an indispensable enzyme to synthesize...
several transcriptional co-activators "TAZ", the gene for muscle protein tafazzin "TAZ", a transcription regulator protein encoded by the gene WWTR1 Taz...
spaetzle-like (German for a type of noodle) shape of the larvae of D. melanogaster Tafazzin Named after the masochistic Italian comic character Tafazzi after alleged...
bacterial infections as compared to non-Barth patients with neutropenia. The tafazzin gene (TAZ, also called G4.5 or NG_009634) is highly expressed in cardiac...
biosynthesis and proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene. 1-acyl-sn-glycerol-3-phosphate acyltransferase...
not to be confused with the protein tafazzin, which originally held the official gene symbol TAZ, and is now TAFAZZIN. WWTR1 contains a proline rich region...
monolysocardiolipin acyltransferase, lysocardiolipin acyltransferase, and tafazzin, which transfer a fourth fatty acid chain onto the phospholipid. Ma BJ...
genes. For instance, another gene with an entirely different function, Tafazzin, is unrelated to EHE but confusingly, also referred to as TAZ. In any case...
which is unrelated to the Hippo pathway. The gene TAZ produces the protein tafazzin. The official gene name for the Hippo TAZ protein is WWTR1. Also, the official...
Strimvelis has been approved in Europe for the treatment of human patients. Tafazzin: a protein discovered in 1996 by Italian scientists Silvia Bione, researcher...
of EFE. A typical example is Barth syndrome and the responsible gene, tafazzin. Developments in echocardiography, both the technology of the machines...
complex finally resulting in a higher stability of β-catenin. Here, YAP/Tafazzin (TAZ) can bind Dvl and reducing its CK1δ-mediated phosphorylation. Additionally...
Global Information
This article incorporates text from this source, which is in the public domain.
