Tablet hardness testing is a laboratory technique used by the pharmaceutical industry to determine the breaking point and structural integrity of a tablet and find out how it changes "under conditions of storage, transportation, packaging and handling before usage"[1]
The breaking point of a tablet is based on its shape.[2] It is similar to friability testing,[1] but they are not the same thing.
Tablet hardness testers first appeared in the 1930s.[3] In the 1950s, the Strong-Cobb tester was introduced. It was patented by Robert Albrecht on July 21, 1953.[4] and used an air pump. The tablet breaking force was based on arbitrary units referred to as Strong-Cobbs.[3] The new one gave readings that were inconsistent to those given by the older testers.[3] Later, electro-mechanical testing machines were introduced. They often include mechanisms like motor drives, and the ability to send measurements to a computer or printer.[3]
There are 2 main processes to test tablet hardness: compression testing and 3 point bend testing. For compression testing, the analyst generally aligns the tablet in a repeatable way,[2] and the tablet is squeezed between a fixed and a moving jaw. The first machines continually applied force with a spring and screw thread until the tablet started to break.[3] When the tablet fractured, the hardness was read with a sliding scale.[3]
^ abCite error: The named reference remington was invoked but never defined (see the help page).
^ ab"Tablet hardness testing". Sotax. Archived from the original on 5 January 2013. Retrieved 16 February 2013.
^ abcdef"Some Information on Tablet Hardness Testing". Engineering Systems. Retrieved 16 February 2013.
^US 2645936, Robert, Albrecht, "Tablet hardness testing machine", published 1953-07-21, assigned to Strong Cobb & Company Inc.
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