Protein-coding gene in the species Homo sapiens
TRIB3 Identifiers Aliases TRIB3 , C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3External IDs OMIM: 607898; MGI: 1345675; HomoloGene: 10902; GeneCards: TRIB3; OMA:TRIB3 - orthologs Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 362,835 bp[1] End 397,559 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 74.83 cM Start 152,179,342 bp[2] End 152,185,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pancreatic ductal cell gonad islet of Langerhans stromal cell of endometrium upper lobe of left lung optic nerve body of pancreas parotid gland anterior pituitary
Top expressed in lumbar spinal ganglion endothelial cell of lymphatic vessel calvaria yolk sac submandibular gland seminal vesicula ascending aorta semi-lunar valve aortic valve olfactory epithelium
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
transcription corepressor activity
ubiquitin-protein transferase regulator activity
protein kinase inhibitor activity
kinase activity
protein binding
mitogen-activated protein kinase kinase binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
Cellular component
cytosol
plasma membrane
nucleus
Biological process
negative regulation of fat cell differentiation
regulation of transcription, DNA-templated
negative regulation of fatty acid biosynthetic process
negative regulation of protein kinase activity
negative regulation of transcription by RNA polymerase II
transcription, DNA-templated
response to endoplasmic reticulum stress
protein phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of ubiquitin-protein transferase activity
cellular response to insulin stimulus
regulation of MAP kinase activity
positive regulation of protein binding
negative regulation of transcription, DNA-templated
regulation of glucose transmembrane transport
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
apoptotic process
regulation of lipid metabolic process
negative regulation of protein kinase B signaling
regulation of autophagy
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_021158 NM_001301188 NM_001301190 NM_001301193 NM_001301196 NM_001301201
RefSeq (protein) NP_001288117 NP_001288119 NP_001288122 NP_001288125 NP_001288130 NP_066981
Location (UCSC) Chr 20: 0.36 – 0.4 Mb Chr 2: 152.18 – 152.19 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[5] [6] [7]
^ a b c GRCh38: Ensembl release 89: ENSG00000101255 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032715 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Du K, Herzig S, Kulkarni RN, Montminy M (Jun 2003). "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver". Science . 300 (5625): 1574–7. Bibcode:2003Sci...300.1574D. doi:10.1126/science.1079817. PMID 12791994. S2CID 43360696.
^ Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci . 63 (14): 1632–41. doi:10.1007/s00018-006-6007-9. PMC 11136108 . PMID 16715410. S2CID 24556931.
^ "Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)".
Last Update: 2024-06-03T07:55:24Z
Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene. The protein encoded by this gene is a putative protein kinase that is induced...
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Last Update: 2024-02-26T04:43:16Z
than apoptosis. ABTL0812 activates the PPAR receptors, inducing TRIB3 over-expression. TRIB3 binds to the Akt oncogene and inhibits the Akt/mTOR axis. ABTL0812...
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Last Update: 2024-04-19T06:06:07Z
Alexander, Daniel C. (2018-03-20). "Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging...
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Last Update: 2024-04-11T11:01:43Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 7803
Last Update: 2024-06-22T03:07:35Z
Fibronectin has been shown to interact with: CD44 COL7A1, LPA, IGFBP3, TNC, and TRIB3 . Fetal fibronectin Fibronectin type I domain Fibronectin type II domain...
Word Count : 3766
Last Update: 2024-01-31T12:46:46Z
are related to the CAMK family include: Tribbles subfamily TRIB1 TRIB2 TRIB3 Swulius MT, Waxham MN (September 2008). "Ca(2+)/calmodulin-dependent protein...
Word Count : 886
Last Update: 2024-06-03T07:22:09Z
substrates such as C/EBPalpha and a key regulatory C-tail region. Like TRIB2 and TRIB3 , TRIB1 has recently been considered as a potential allosteric drug target...
Word Count : 921
Last Update: 2024-02-08T05:33:18Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 1616
Last Update: 2024-04-06T17:03:51Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 2665
Last Update: 2024-05-28T16:07:37Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 12654
Last Update: 2024-04-23T20:14:11Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 3754
Last Update: 2024-03-19T21:16:28Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 2650
Last Update: 2024-06-02T00:07:56Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 4670
Last Update: 2024-06-03T05:05:07Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 6278
Last Update: 2024-06-20T01:59:44Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 1031
Last Update: 2024-06-29T03:07:00Z
this episode. Humans carry three homologs of tribbles, TRIB1, TRIB2, and TRIB3 . The parasprites in the My Little Pony: Friendship Is Magic episode "Swarm...
Word Count : 7817
Last Update: 2022-12-14T01:11:42Z
PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1 Myosin light-chain kinase (EC 2.7.11.18) MYLK MYLK2 MYLK3...
Word Count : 334