TMEM248 information

TMEM248
Identifiers
Aliases	TMEM248, C7orf42, transmembrane protein 248
External IDs	MGI: 1918917; HomoloGene: 9951; GeneCards: TMEM248; OMA:TMEM248 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	66,958,551 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	130,272,606 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tendon of biceps brachii; ; stromal cell of endometrium; ; epithelium of colon; ; cartilage tissue; ; gallbladder; ; rectum; ; right lung; ; thoracic aorta; ; ascending aorta;
	Top expressed in
	lacrimal gland; ; seminal vesicula; ; parotid gland; ; decidua; ; seminiferous tubule; ; otolith organ; ; utricle; ; islet of Langerhans; ; submandibular gland; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Orthologs
	55069
	71667
	ENSG00000106609
	ENSMUSG00000053094
	Q9NWD8
	Q3TBN1
	NM_017994
	NM_001081394; NM_027854
	NP_060464
	NP_001074863; NP_082130
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 248, also known as C7orf42, is a gene that in humans encodes the TMEM248 protein. This gene contains multiple transmembrane domains and is composed of seven exons.TMEM248 is predicted to be a component of the plasma membrane and be involved in vesicular trafficking.^[1]^[2] It has low tissue specificity, meaning it is ubiquitously expressed in tissues throughout the human body. Orthology analyses determined that TMEM248 is highly conserved, having homology with vertebrates and invertebrates. TMEM248 may play a role in cancer development. It was shown to be more highly expressed in cases of colon, breast, lung, ovarian, brain, and renal cancers.^[3]

^ "TMEM248 transmembrane protein 248 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-20.
^ "TMEM248 Polyclonal Antibody (PA5-53435)". www.thermofisher.com. Retrieved 2022-12-15.
^ Sehovic, Emir; Hadrovic, Adem; Dogan, Senol (2019-11-10). "Detection and analysis of stable and flexible genes towards a genome signature framework in cancer". Bioinformation. 15 (10): 772–779. doi:10.6026/97320630015772. ISSN 0973-2063. PMC 6900328. PMID 31831960.
^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106609 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-1] "TMEM248 transmembrane protein 248 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-09-20.

[:1-2] "TMEM248 Polyclonal Antibody (PA5-53435)". www.thermofisher.com. Retrieved 2022-12-15.

[3] Sehovic, Emir; Hadrovic, Adem; Dogan, Senol (2019-11-10). "Detection and analysis of stable and flexible genes towards a genome signature framework in cancer". Bioinformation. 15 (10): 772–779. doi:10.6026/97320630015772. ISSN 0973-2063. PMC 6900328. PMID 31831960.

[refGRCh38Ensembl-4] GRCh38: Ensembl release 89: ENSG00000106609 – Ensembl, May 2017

[refGRCm38Ensembl-5] GRCm38: Ensembl release 89: ENSMUSG00000053094 – Ensembl, May 2017

[6] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[7] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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