TLL1 information

TLL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EDI
Identifiers
Aliases	TLL1, ASD6, TLL, tolloid like 1
External IDs	OMIM: 606742; MGI: 106923; HomoloGene: 49202; GeneCards: TLL1; OMA:TLL1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	166,104,457 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	64,659,305 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; testicle; ; cerebellar cortex; ; cerebellar hemisphere; ; epithelium of colon; ; right hemisphere of cerebellum; ; Achilles tendon; ; gallbladder; ; smooth muscle tissue;
	Top expressed in
	muscular part of interventricular septum; ; cardiac muscle tissue of interventricular septum; ; Aorticopulmonary septum; ; vein; ; endocardium of atrium; ; interatrial septum; ; septum primum; ; endocardium of right atrium; ; zygote; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; serine-type endopeptidase activity;
Cellular component	extracellular region;
Biological process	multicellular organism development; skeletal system development; cell differentiation; extracellular matrix disassembly; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	7092
	21892
	ENSG00000038295
	ENSMUSG00000053626
	O43897
	Q62381
	NM_001204760; NM_012464
	NM_009390
	NP_001191689; NP_036596
	NP_033416
	Wikidata
View/Edit Human	View/Edit Mouse

Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.^[5]^[6]

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000038295 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053626 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–65. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
^ ^a ^b "Entrez Gene: TLL1 tolloid-like 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000038295 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053626 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10516436-5] Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–65. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.

[entrez-6] "Entrez Gene: TLL1 tolloid-like 1".

TLL1 information

and 7 Related for: TLL1 information

TLL1

Subdivisions of Wales

CUB domain

Chordin

Astacin

List of OMIM disorder codes

TLL2