TLE4 information

TLE4
Identifiers
Aliases	TLE4, BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4, transducin like enhancer of split 4, TLE family member 4, transcriptional corepressor, E(spl)
External IDs	OMIM: 605132 MGI: 104633 HomoloGene: 38259 GeneCards: TLE4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	79,726,882 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	14,575,415 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; endothelial cell; ; corpus callosum; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; Region I of hippocampus proper; ; bone marrow cells; ; external globus pallidus; ; subthalamic nucleus; ; germinal epithelium;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; superior cervical ganglion; ; suprachiasmatic nucleus; ; conjunctival fornix; ; nucleus accumbens; ; retinal pigment epithelium; ; olfactory tubercle; ; pineal gland; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin binding; protein binding; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; molecular function;
Cellular component	nucleus; nucleoplasm; transcription regulator complex; beta-catenin-TCF complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; beta-catenin-TCF complex assembly; cellular response to leukemia inhibitory factor; biological process; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7091
	21888
	ENSG00000106829
	ENSMUSG00000024642
	Q04727
	Q62441
NM_001282748; NM_001282749; NM_001282753; NM_001282760; NM_007005;
	NM_001351541; NM_001351542; NM_001351543; NM_001351546; NM_001351547; NM_001351550; NM_001351552; NM_001351558; NM_001351560; NM_001351562; NM_001351563; NM_001351564; NM_001351556
	NM_011600; NM_001302947; NM_001302950; NM_001302951
NP_001269677; NP_001269678; NP_001269682; NP_001269689; NP_008936;
	NP_001338470; NP_001338471; NP_001338472; NP_001338475; NP_001338476; NP_001338479; NP_001338481; NP_001338487; NP_001338489; NP_001338491; NP_001338492; NP_001338493; NP_001338485
	NP_001289876; NP_001289879; NP_001289880; NP_035730
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106829 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024642 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
^ "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106829 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024642 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8365415-5] Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.

[entrez-6] "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".

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